Development of extracellular vesicle (EV)-based diagnostics and therapeutics

Abstract

The term “Mi-byo” is increasingly used nowadays like a buzzword since people are afraid of diseases that may eventually fall on themselves with aging. In addition, it is also known that one out of two Japanese has cancer. Thus, it is necessary to identify the marker used to judge the health condition of humans, which is represented by the word “pre-disease”. Pre-disease is a condition in which no special abnormality is found even after undergoing an examination, and a specific illness is not diagnosed, but it cannot be said that the person is healthy. Many studies state that it is likely that it will cause illness if left unchecked. Thus, persons suffering from conditions such as hyperlipidemia, diabetes, and hypertension, can be considered as “undiseased”. However, it is important to develop new biomarkers or tools to quickly find the signs of these diseases and restore them to their original state. Therefore, in this review, I will overview the recent progress of a novel approach to diagnostic and therapeutic needs using small particles named extracellular vesicles (EVs).