Abstract
Little information is available on the molecular mechanisms underlying oncogenesis of dedifferentiated chondrosarcoma. To obtain an overview of the genomic imbalances characterizing this tumor, we analyzed by karyotypes and comparative genomic hybridization (CGH) and reviewed the previous literatures. Cytogenetically, multiple complex abnormalities were observed in each case, but dedifferentiated chondrosarcoma has not shared common abnormal changes in karyotypes. The chondroid portion and anaplastic portion showed similar karyotype suggesting monoclonal origin, not collision tumor. The conspicuous CGH results suggested that chromosome 9 was most critical region in dedifferentiated chondrosarcoma. It may therefore supply a possible data of oncogenic mechanism of this tumor.
