2022 Volume 38 Pages 15-17
Salt-like cocrystals of favipiravir (FVR) with monoethanolamine (MEA) (I) and ethylendiamine (en) (II) have been determined by X-ray crystallography. The crystallographic data are (1), monoclinic P21/c, Z = 4, a = 12.2433(3), b = 22.5400(5), c = 7.3223(3)Å, β = 106.287(3)°, V = 1939.6(1)Å, R1 = 0.0499; (II), triclinic P1, Z = 2, a = 8.5903(12), b = 9.4980(10), c = 10.0337(13), α = 83.464(10), β = 79.338(11), γ = 80.665(10)Å, V = 790.90(18)Å3, R = 0.0709. In both of compounds, FVR is a single charged anion with a deprotonated 2-hydroxyl group. The asymmetric unit of the lattice consists: (1) of two FVR anion and two MEA cations; (2) of two FVR anions and one a double charged en cation.
