2020 Volume 12 Issue 2 Pages 74-83
Infection caused by drug resistant bacterium is one of the global issues. Therefore, in April, 2016, Ministry of Health, Labour and Welfare formulated the National Action Plan on AMR and is working on proper use of antibiotics. In this study, we investigated the receipt data of our 248 pharmacies which operated by the group from April 2013 to March 2019. The effect of the Action Plan on AMR was determined by segmented regression analysis of interrupted time series for the prescription number of times and the prescriptions days of antibiotics. According to the formulation of the AMR action plan, changes in the prescription times of antibiotics was −202.3 times/month (95% Confidence interval (CI) −325.7, −79.0), and the prescription days was −1905.9 days/month (95%CI −2969.0, −842.9). In addition, the monthly means of the prescription number of times of the oral third generation cephem antibiotics, the 14-membered ring macrolide antibiotics, and the new quinolone antibiotics also showed a significant decreasing from April 2015 to March 2019. Based on these results, the AMR action plan is thought to have reduced the number of prescription times and prescription days for antibacterial drugs in pharmacies.
