2016 Volume 65 Issue 2 Pages 95-100
Background：Adenosquamous carcinoma（Adsq）and large cell carcinoma with neuroendocrine morphology（LCCNM）are rare histologic types of primary lung cancer. The metachronous occurrence of these types has not been reported previously in Japan.
Case：A man in 80s had undergone whole larynx enucleation for laryngeal cancer when he was in 60s. Partial lung resection was performed because a nodular shadow was detected in the middle and lower lobes of the right lung on chest computed tomography（CT）before the laryngeal surgery, but the nodules were found to be benign. Seven years later, CT showed a nodular shadow in all lobes of the right lung. On suspicion of metastatic laryngeal cancer, partial lung resection was performed. However, all the nodules were histopathologically diagnosed with LCCNM. Three years thereafter, partial lung resection was performed again because of a nodular shadow in the upper lobe of the right lung on CT. The nodule was histopathologically classified as Adsq. Five years later, a fourth lung operation was performed because of a nodular shadow in the lower lobe of the right lung on CT, which was diagnosed as Adsq.
Conclusion：We report a rare case who got long-term survival by lung operation of metachronous multiple lung cancers with LCCNM and Adsq.
