2020 Volume 69 Issue 2 Pages 81-86
We herein report an experience of neuroendocrine carcinoma of the breast. A 73-year-old woman visited our hospital because of a tumor of the left breast. The tumor was diagnosed as category 3 by mammography. Ultrasonography diagnosed as 16mm size in diameter with relative clear margin in D area in the left breast. Imaging of MRI showed the tumor had early enhancement following gradual decreasing. PET displayed a slight accumulation of FDG on the tumor. Biopsy of the tumor was diagnosed as invasive carcinoma histologically. We performed partial mastectomy of left breast and sentinel lymph node biopsy. Tumor cells were demonstrated having formation of Rosset and pseudo-Rosset in perivascular lesion histopathologically. Tumor cells were displayed as positive of Chromogranin A stain, positive of NSE stain, slight positive of CD56 stain, and positive of Synaptophysin stain immune-pathologically. The tumor was made a definite diagnosis as poorly differentiated neuroendocrine carcinoma having many mitotic figures and strong cellular atypia. After surgery the patient received radiation therapy and has been under follow-up observations with medication of aromatase inhibitor. Generally atypical carcinoid is said to be high grade of malignancy, so this case should be under careful observation in a long-term.
