Abstract
This study aimed to optimize two-stent treatment for left main coronary artery（LM）lesions and explore a novel approach in cardiovascular disease therapy. LM lesions present a significant threat to patient prognosis and require complex interventional techniques. We developed a new LM bifurcation lesion model that simulates cardiac motion, and investigated the standardization of techniques using 3D optical coherence tomography（OCT）guidance and optimal stent selection. This human-like simulation system provides a new methodology for pre-clinical assessment of treatment strategies, serving as an alternative to clinical trials for evaluating the safety and efficacy of the treatments. The results suggest that, given the current immaturity of two-stent procedures, the use of stent platforms with maximum expansion diameter, along with advanced imaging technologies such as 3D-OCT, can significantly improve treatment success rates. The evaluation of treatment strategies using this engineering-based model is expected to play a crucial role in the future development of medical technologies, improving the quality of care for patients and contributing to better outcomes in cardiovascular disease.
