Abstract
We report a case of granulocyte-colony stimulating factor（G-CSF）-producing esophageal carcinosarcoma in a 59-year-old female who presented with dysphagia. Elevated CRP levels and fever were noted before referral, and blood G-CSF levels were elevated at 52.2 pg/ml, raising suspicion of G-CSF-producing esophageal cancer. Diagnostic treatment consisted of subtotal esophagectomy with lymphadenectomy and gastric tube reconstruction via the posterior mediastinal route. Pathological examination revealed sarcomatous components within the tumor, along with moderately differentiated squamous cell carcinoma. Positive immunostaining for anti-G-CSF antibodies confirmed the diagnosis of G-CSF-producing esophageal carcinosarcoma. Postoperatively, leukocyte count, CRP, and blood G-CSF levels showed a decreasing trend. Despite complications such as bleeding and chylothorax, the patient was discharged home on postoperative day 52. With no adjuvant therapy, the patient remains recurrence-free and alive 7 years and 3 months postoperatively. While G-CSF-producing esophageal carcinosarcoma generally carries a poor prognosis, cases with relatively well-differentiated components may not necessarily have a poor prognosis.
