2005 Volume 58 Issue 2 Pages 104-106
This study aimed to determine the levels of the macrolides-lincosamides-streptogramins B (MLSB) resistance phenotype in Staphylococcus aureus and coagulase-negative staphylococci (CNS) isolates from clinical samples. A total of 521 strains of staphylococci, comprising 230 S. aureus and 291 CNS isolates from various clinical samples, were identified by conventional methods. The double-disc test was applied by placing erythromycin and clindamycin discs on these isolates to investigate the inducible and constitutive MLSB resistance phenotypes and MS phenotype. Among the S. aureus strains, 24.3% showed the constitutive and 7.8% the inducible phenotype, while there was no MS phenotype. In the CNS strains, 40.2% showed the constitutive and 14.7% the inducible MLSB resistance phenotype, and 18.2% had the MS phenotype. In both S. aureus and CNS strains, the constitutive MLSB resistance rate was found to be higher than the rate of inducible resistance. By applying double-disc tests on a routine basis to detect inducible MLSB resistance, clindamycin can be effectively used on staphylococcal infections. Additionally, it can be used to survey the MLSB resistance of staphylococci strains from specific geographical regions or hospitals.
