Japanese Journal of Infectious Diseases
Online ISSN : 1884-2836
Print ISSN : 1344-6304
ISSN-L : 1344-6304
Chikungunya fever in Japan imported from the Caribbean islands
Kazuo ImaiEri NakayamaTakuya MaedaKei MikitaYukiko KobayashiAoi MitaraiYasuko HonmaSatoru MiyakeKoki KakuYasushi MiyahiraAkihiko Kawana
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Article ID: JJID.2015.063


A 53-year-old Japanese woman who was working as a volunteer in the Commonwealth of Dominica in the Caribbean islands presented with a high-grade fever and severe incapacitating generalized arthralgia. The Asian genotype of the chikungunya virus was confirmed with RT-PCR and serology, based on the presence of specific neutralization titer and IgM antibody. She was diagnosed with post-chikungunya chronic arthritis based on persistence of her polyarthritis for 3 months and the presence of rheumatoid factor, immunoglobulin G-rheumatoid factor, and matrix metalloproteinase-3. Chikungunya virus should be considered as a causative pathogen in travelers returning from Caribbean islands. Clinicians should consider chikungunya fever in the differential diagnosis of patients who complain of chronic arthritis and have a history of travel to an endemic area.

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