Abstract
The presepsin level (a soluble CD14 subtype) is thought to increase in cases of bacterial infection. It has been stated that CD 14 also plays a role in the pathogenesis of various viral diseases. Crimean-Congo Hemorrhagic Fever (CCHF) is an arboviral zoonotic infection. Our study focuses on the presepsin level as a biomarker for CCHF. Serum presepsin levels in CCHF group (n=59) and control (n=28) have been compared. Patients with CCHF have been classified as mild, moderate and severe groups (group 1, 2 and 3 respectively) in terms of the Severity Grading Score (SGS). Presepsin levels were measured in serum samples using a commercial ELISA. The mean presepsin levels were found to be significantly different in the CCHF and healthy group (1499.46±411.96 pg/ml and 430.68±61.21 pg/ml, respectively). The mean presepsin levels were found to be significantly different in the CCHF groups (1, 2, 3) and healthy group (1204.53±371.18, 1464.21±338.37, 2007.36±82.18 and 430.68±61.21 pg/ml, respectively) (p<0,05). We have also found out that as the severity of the disease increases, the presepsin value increases. We are of the opinion that presepsin values could be used as a supportive biomarker for diagnosis and follow-up of the disease.
