Japanese Journal of Infectious Diseases
Online ISSN : 1884-2836
Print ISSN : 1344-6304
ISSN-L : 1344-6304
Spatial Clustering of Severe Hand-Foot-Mouth Disease Cases in Hainan Island, China
Shao-Ming ChenLi QiuZhong-Hua DuYu-Ming JinJian-Wei DuYan ChenChiho WatanabeMasahiro Umezaki
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JOURNAL FREE ACCESS Advance online publication

Article ID: JJID.2016.407


  The incidence of severe Hand-Foot-Mouth disease (HFMD) in Southeast/East Asia has recently increased. This study explored spatial clusters of the incidence and proportion of severe HFMD cases in Hainan Island, Where the prevalence and mortality of HFMD were the highest in China in 2011. A spatial autocorrelation statistic (Anselin’s Local Moran I) was calculated for the Empirical Bayesian (EB) smoothed dataset of severe HFMD cases. Significantly spatial clusters were detected for both incidence and the proportion of severe HFMD cases. Population density was higher in spatial clusters with a high proportion of severe HFMD cases among total HFMD cases. We speculate that a higher proportion of severe HFMD cases were diagnosed in densely populated townships. This should be considered when analyzing the HFMD database of Hainan.

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