Article ID: JJID.2017.087
Dengue is found to be the most prevalent arboviral disease affecting humans. Tropical and subtropical regions are at high risk of dengue virus infections. The clinical manifestations often range from mild fever to fever with hemorrhagic manifestations and shock. Since 2010, India is witnessing a marked increase in the number of Dengue Virus Serotype 1(DENV-1) apart from Dengue Virus 2 (DENV-2) and Dengue Virus 3 (DENV-3) Serotypes. The present study was undertaken to understand the circulating genotypes of DENV-1 in South West India by sequencing the envelope gene of DENV-1 samples representative of the time period 2014-2015. The extracted RNA from Dengue NS1 antigen ELISA positive samples, archived at Manipal Centre for Virus Research (MCVR), National Vector Borne Disease Control Apex referral laboratory for arboviruses were employed for the study. The currently circulating genotypes of DENV-1 identified from the study area belonged to genotypes V and I. Multicentric laboratory-based studies analysing the envelope gene of all dengue serotypes are required from endemic countries like India.