Japanese Journal of Infectious Diseases
Online ISSN : 1884-2836
Print ISSN : 1344-6304
ISSN-L : 1344-6304

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Isolation and complete genome sequencing of Zika virus imported from the Dominican Republic to Japan
Hiroki OzawaShigeru TajimaEri NakayamaKengo KatoAkifumi YamashitaTsuyoshi SekizukaMakoto KurodaShuzo Usuku
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JOURNAL FREE ACCESS Advance online publication

Article ID: JJID.2017.256

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Abstract

  Zika virus (ZIKV) infection has been documented within Central and South America, Asia, and Africa. Here we report the isolation of virus from a patient infected with ZIKV returning to Japan from the Dominican Republic. The ZIKV strain was imaged by electron microscopy and its complete genome sequence was analyzed. Phylogenetic analysis and molecular characterization revealed that the strain was of the Asian lineage, and carried two unique mutations in its NS5 region. These mutations are characteristic of strains that originated in the Dominican Republic and the USA in 2016.

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