Genome Recombination between Delta and Alpha Variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Tsuyoshi Sekizuka; Kentaro Itokawa; Masumichi Saito; Michitsugu Shimatani; Shutoku Matsuyama; Hideki Hasegawa; Tomoya Saito; Makoto Kuroda

doi:10.7883/yoken.JJID.2021.844

This article has now been updated. Please use the final version.

Genome Recombination between Delta and Alpha Variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Tsuyoshi Sekizuka, Kentaro Itokawa, Masumichi Saito, Michitsugu Shimatani, Shutoku Matsuyama, Hideki Hasegawa, Tomoya Saito, Makoto Kuroda

Author information

Keywords: SARS-CoV-2, Genome recombination, Alpha variant, Delta variant

JOURNAL FREE ACCESS Advance online publication

Article ID: JJID.2021.844

DOI https://doi.org/10.7883/yoken.JJID.2021.844

The final version of this article is now available: Vol. 75 (2022), No. 4 pp. 415-418

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Abstract

Prominent genomic recombination has been observed between the Delta and Alpha variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated from clinical specimens in Japan. Interestingly, the recombination variant detected in this study carries a spike protein identical to the one in the domestic Delta variant, thereby suggesting that further risks would not be concerned with infectivity and immune escape. The recombinant has been classified as XC lineage in the PANGOLIN database. It is necessary to intensively study such marked genetic variations and characterize the emerging variants after careful verification of their lineage and clade assignment.

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