Monomicrobial Necrotizing Fasciitis and Sepsis Caused by Pseudomonas aeruginosa and Pseudomonas fluorescens: A Series of Ten Cases

Abstract

Monomicrobial necrotizing fasciitis caused by Pseudomonas species is a rare infection. The purpose of this study was to elucidate the specific characteristics and clinical outcomes of necrotizing fasciitis caused by Pseudomonas aeruginosa and Pseudomonas fluorescens. Ten patients with monomicrobial necrotizing fasciitis caused by Pseudomonas species were retrospectively reviewed over an 8-year period. Differences in mortality, patient characteristics, clinical presentations, laboratory data, and clinical outcomes were compared between the death and the survival groups. Two patients died with the mortality rate of 20%. Pseudomonas aeruginosa accounted for 9 patients and Pseudomonas fluorescens for one patient. The most common comorbidity is type 2 diabetes mellitus in 5 patients. We found the death patients had lower albumin level and higher counts of band forms of leukocytes than those of the survival patients. Monomicrobial necrotizing fasciitis caused by Pseudomonas species needs emergent surgical intervention and aggressive intensive care due to high mortality rate. We reported the first case of monomicrobial necrotizing fasciitis with Pseudomonas fluorescens. Severe hypoalbuminemia and increased counts of banded leukocytes in initial laboratory presentations can be considered as poor prognostic factors.