Article ID: JJID.2022.288
Lung carcinoma is one the most common cancer and the leading cause of cancer-related death worldwide. Increasing evidences have shown that Cryptosporidium spp., an opportunistic parasite, is associated with cancers, causing a life-threatening infection. The most common clinical form of Cryptosporidium is intestinal infection. However, respiratory cryptosporidiosis has been rarely documented although the parasite infects respiratory epithelium cells as well as GIS epithelium cells. To evaluate respiratory cryptosporidiosis in patients with lung cancer, we investigated Cryptopsoridium spp. in patients with lung cancer (n=69) by comparing with healthy groups (n=40). Sputum and stool samples were tested by microscopic examination and polymerase chain reaction. Two cancer patients were diagnosed with respiratory cryptosporidiosis (2.9%), by PCR examination of the sputum samples. Cryptopsoridium spp. was detected in the stool sample of one patient (1.5%), and two healthy individuals (5.4%), by PCR and microscopy. Firstly, respiratory cryptosporidiosis was documented in two patients with lung cancer. Cryptosporidium is an important agent of respiratory tract infection as well as GIS infection, in cancer patients. These new findings highlight the molecular prevalence of Cryptosporidium spp., an opportunistic infection, in patients with lung cancer, and respiratory cryptosporidiosis should also be considered when patients have respiratory symptoms.
