Continuous renal replacement therapy improves indicators and short-term survival in people with AIDS manifesting sepsis and acute kidney injury

Abstract

Acquired immune deficiency syndrome (AIDS) is susceptible to numerous complications such as sepsis and acute kidney injury (AKI), leading to adverse outcomes. Continuous renal replacement therapy (CRRT) is becoming increasingly popular in the treatment of sepsis and AKI. This study aimed to verify the effectiveness of CRRT in the treatment of AIDS with sepsis and AKI, to provide new directions for the treatment of severe AIDS. Data of 74 people with AIDS, sepsis and AKI were collected. They were divided into CRRT and non-CRRT groups. There was no difference in indicators between the two groups at admission. Vital signs, PH, serum potassium, renal function, blood lactate, APACHE II score, and SOFA score in CRRT group demonstrated significant improvements over those in the non-CRRT group both 24 and 72 hours after admission (P＜0.05). Level of Interleukin 6 and procalcitonin declined more significantly in CRRT group 72 hours after admission (P＜0.05). CRRT group had a higher 28-day survival rate (P＜0.05). CRRT improves the clinical indicators and increases the short-term survival rate of people with AIDS, sepsis and AKI.