Abstract
The exprimental as well as clinical studies in the therapy of typhoid fever have far advanced since the appearance of sulfonamide preparations and antibiotics. Nagabayashi (1945) reported that 80-90% of mice, infected with E. typhosa, survived by the treatment with self athiazole, the results of which could not be confirmed by the authors, perhaps because the virulence and the amount of bacilli used by us were different from that of Nagabayashi.
Next Bigger (1946) investigated the additive action of penicillin and sulf athiazole upon the growth of E. typhosa in vitro and in the same year Mc Sweeney reported that they had obtained good results in clinical cases of typhoid fever by the combined medication of penicillin and sulfathiazole.
Mikamo (1948) used patulin in combination with sulfathiazole for the patients of typhoid fever and concluded as follows : Bacillemia disappears in course of the use of drugs or directly after the interruption of drug administration ; the temperature does not rise temporarily and it seems that the general conditions turn for the better. The stop of medication invites, however, the relapse of the disease. Patulin itself is toxic and its great amount can not be used.
Prior to this a great success was expected about the effect of streptomycin upon typhoid fever but the report of Keefer and his collaborators (1946) in 51 clinical cases was contrary to their expectations.
And in recent times chloromycetin is the only hopeful substance to heal typhoid fever according to the report of Smadel, Joseph, Léon, Ley and Varela, while the details thereabout are not known to us as yet.
Now our report concerns also with the therapeutic study of typhoid fever and the discovery of complete protection of mice against E. typhosa infection by our procedure is believed to promote the study in this field.
