STUDIES ON SABIN VACCINE ADMINISTRATION IN NAGAOKA CITY IN 1960

Abstract

Nagaoka City, a city with a population of about 150, 000 in Niigata prefecture, experienced an epidemic of poliovirus type 2 infections in 1958 in which 21 paralytic cases were observed, showing a case incidence of approximately 40 per 100, 000 population (Saito et al., 1960, Kitaoka, 1960) . The Health Authorities of the city had been interested in introducing protective measures against polio infections. On the other hand, live oral poliovirus vaccine had been studied more and more widely (First and Second International Conference on Live Poliovirus Vaccine, 1959 & 1960) and in 1959 one of the authors (M. K.) received Sabin's original vaccine from Dr. A. B. Sabin for field trial in Japan. The first field trial of Sabin vaccine in Japan was thus undertaken in Nagaoka City in 1960. The following is the outline and results of the trial.