Abstract
When typhoid vaccine was injected to Clonorchis sinensis infestated guinea pigs, the titer of the H-agglutinins in response to the injection was reduced in the infestated animals as compared with the uninfestated controls. Moreover, the heavier the infestation the lower was the agglutinin response. It was suggested that compression of the liver cells by the fibrosis around intrahepatic bile ducts as a result of the infestation contributed to the variation in antibody response in the infestated animals.
