Biken-CAM and Sugiyama-3 vaccines developed in Japan were studied in a field trial involving about 1000 seronegative children, 8 months to 6 years of age, along with Schwarz, Leningrad-16 and ESC vaccines which had been extensively tested by other workers.
All vaccines produced a satisfactory serologic response except Biken-CAM vaccine which failed to induce antiboby in one-fifth of vaccinated children. This unsatisfactory result of Biken-CAM vaccine is obviously due to an insufficient dose of virus as other data indicate. The vaccines induced clinical reactions such as pyrexia and rash, but no side reactions of any consequence. The overall assessment of the clinical data seem to indicate that in clinical reactions ESC vaccine is mildest, Schwarz and Leningrad-16 vaccines are less mild, and Biken-CAM and Sugiyama-3 vaccines still somewhat less mild. The two Japanese vaccines, however, are obviously much more attenuated as compared with those licensed live vaccines of Japan, and seem to belong to a group of further attenuated vaccines which can be administered without gamma globulin or prior inoculation of killed vaccine.
