CONTRIBUTION A L'ETUDE DE LA NEUROIMMUNOMODULATION DE LA REPONSE IMMUNITAIRE PAR LE SYSTEME ENDOCRINIEN: EFFET DE L'HORMONE LUTEINISANTE (LH) SUR LA REPONSE PROLIFERATIVE DESLYMPHOCYTES

Abstract

Proliferative response of splenic lymphocytes from adult (2 months old) male mice to human luteotrophic hormone (hLH) was studied in vitro. hLH induced lymphoblastic transformation at a concentration of 0.1μg/ml or higher. This hormone potentiated the mitogen activities of concanavalin A (ConA) and phytohemagglutinin (PHA) for T cells and of pokweed mitogen for B and T cells. The data suggest that peripherally circulating LH may regulate a certain function of lymphoid cells.