EFFECT OF N- (3-PHENYL-2-PROPENYL) -1-DEOXYNOJIRIMYCIN ON THE LECTIN BINDING TO HIV-1 GLYCOPROTEINS

Hiroyuki SHIMIZU; Hideaki TSUCHIE; Hitoshi HONMA; Kiyoshi YOSHIDA; Takashi TSURUOKA; Hiroshi USHIJIMA; Takashi KITAMURA

doi:10.7883/yoken1952.43.75

Hiroyuki SHIMIZU, Hideaki TSUCHIE, Hitoshi HONMA, Kiyoshi YOSHIDA, Takashi TSURUOKA, Hiroshi USHIJIMA, Takashi KITAMURA

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 3 Pages 75-87

DOI https://doi.org/10.7883/yoken1952.43.75

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Abstract

The effect of N- (3-phenyl-2-propenyl) -1-deoxynojirimycin (ppDNM) on the lectin binding to HIV-1 glycoprotein was analyzed by using biotinylated lectins of various sugar specificities as probes. ppDNM potentially inhibited HIV-1-induced syncytium formation and viral infectivity of HIV-1 without cytotoxicity. The lectin binding assay showed that ppDNM treatment reduced Con A binding to gp120 of HIV-1.

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