Basaloid cell carcinoma originating in the esophagus is a rare disease classified as an epithelial malignancy. Compared ith squamous cell carcinoma, basaloid cell carcinoma of the esophagus is generally associated with poor prognosis, involvng extensive vascular invasion and causing extensive lymph node and hematogenous metastases. A 69-year-old male patient ad no chief complaint. An elevated lesion was found in the esophagus in the upper gastrointestinal contrast examination erformed as part of the health checkup. A 10-mm-diameter nodular, elevated lesion slightly dented at the center was found t 34 cm from the incisor in esophageal endoscopy. The histological examination of a biopsy specimen revealed cancer cells esembling poorly-differentiated squamous cell carcinoma. cStage I esophageal cancer (Lt 0-IIa, T1bN0M0) was diagnosed nd surgically removed. The patient underwent a subtotal esophagectomy with two regional lymph nodes (thoracic lymph des and abdominal lymph nodes) dissection via a right thoraco-laparotominal approach and reconstruction of the esophaogastric tube anastomosis at the upper mediastrium area. The histopathology of the removed sample showed squamous ell carcinoma in the superficial epithelium and non-invaded part. The tumor cells had invaded the upper submucosal layer nvolving basaloid cell carcinoma. Based on the findings, superficial basaloid cell carcinoma of the esophagus was diagsed (pT1b pN0 pM0 ly0 v0 pStage I). The patient had a good postoperative course and was discharged at about 3 weeks fter surgery. No adjuvant chemotherapy has been performed. Currently at about 4 years postoperation, the patient is being ollowed up on an outpatient basis without recurrence.
We report a 38-year-old man with poor performance status (PS) who was diagnosed as stage IV non-small cell lung cancer (NSCLC) harboring the echinoderm microtubule-associated protein like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene. Crizotinib, an ALK inhibitor, was administered after a temporary effect of combination cytotoxic chemotherapy. Chest computed tomography showed air space consolidations and diffuse ground glass opacities in the both lungs after 5 days of treatment with crizotinib, and the patient required mechanical ventilation due to respiratory deterioration. For tumor progression, crizotinib was switched to alectinib, the other ALK inhibitor, along with short-term corticosteroid therapy for the possibility of crizotinib-induced pneumonitis. After alectinib administration through a nasogastric tube, tumors regressed with weaning from mechanical ventilation. Safe and successful administration of alectinib through a nasogastric tube may be a therapeutic option for the ALK-positive NSCLC patient with poor PS who fails to take oral medications.
The prognostic relevance of the mucinous subtype of colorectal cancer is still controversially discussed. We designed a large-scale cohort study with a propensity score matching to evaluate the impact of mucinous subtype on postoperative survival, recurrent patterns and chemo-sensitivity in patients with colorectal cancer using the integrated database of three phase III clinical trials. We introduce a study concept and present preliminary results of an overview of the total individual patients’ data here.
Isolated paraaortic lymph node metastasis or peritoneal dissemination as first site of recurrence after curative surgery in patients with colorectal cancer is relatively uncommon. Early detection is necessary to allow for treatment of these rare types of recurrences. We conducted a pooled analysis of large three randomized control studies to clarify the risk factors for these recurrences. We hereby report the study concept.
Estimation of the risk for tumor recurrence after curative resection of colorectal cancer is essential for establishment of a treatment plan and surveillance schedule. Several studies have identified the risk factors for the tumor recurrence occurring within a specific period of time, but the knowledge concerning the transition of the hazard rate over time and the effect of clinical variables on it is scarce.
Herein, we would like to introduce the concept of the present study with summarized methods, and to report the fixation of the data and completion of the analysis.