Personalized therapy based on targetable genetic aberrations has become a standard therapy for cases of lung adenocarcinoma (LADC) harboring EGFR mutations and ALK fusions. The effects of such personalized therapy are significantly positive with a higher response rate and longer survival compared to conventional chemotherapy. Therefore, further identification of druggable genetic aberrations and the development of molecular targeting drugs for them are required. For LADC, several new targeted drugs against driver mutations in EGFR, KRAS, HER2, and BRAF; and driver fusions involving ALK, RET, and ROS1 have been developed, and clinical trials of these new targeted drugs are currently being conducted. On the other hand, personalized therapy against driver mutations has not well progressed in squamous cell lung cancer and small cell lung cancer. For those subtypes, immunotherapy might be an effective treatment strategy.
Background: Single port laparoscopic surgery has been rapidly developing worldwide, with the potential for replacing conventional laparoscopic surgery. Objective: Identification and evaluation of the safety, benefits and disadvantages of single port laparoscopic procedures through presentation of our experience. Design: Retrospective review of surgical procedures and outcomes for two-hundred-fifty-eight consecutive cases of single port laparoscopic surgery for colorectal cancers, between September 2009 and March 2015. Main Outcomes: Descriptive analysis of patients’ background characteristics (age, sex and cancer location), operative details (type, duration, intra-operative bleeding volume, intra-operative complication, conversion to open surgery), and postoperative follow-up (complications within 30 days). Results: Cases included ileocaecal resection (n=36), right hemicolectomy (n=54), transverse colectomy (n=21), left hemicolectomy (n=25), sigmoidectomy (n=33), high anterior resection (n=68), low anterior resection (n=24), and abdominoperineal resection (n=1). Patient group included 137 men, 121 women, with a median age of 71 years (range, 26-94). Operative details included a median duration of 234.5min (range, 90-541) and a median blood loss was 70ml (range, 0-2560). The median follow-up period was 253 days (range, 13-703), with 21 reported complications in 17 patients. Conclusions: Single-port transumbilical laparoscopic surgery is feasible and safe provided that the surgery is performed by experienced surgeons, compared to multiport laparoscopic procedures for colorectal cancers.