Annals of Nuclear Cardiology
Online ISSN : 2424-1741
Print ISSN : 2189-3926
Advance online publication
Advance online publication

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Showing 1-2 articles out of 2 articles from Advance online publication
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  • Shinichiro Fujimoto, Keiichiro Yoshinaga
    Article ID: 18-00051
    [Advance publication] Released: February 28, 2018
    JOURNALS FREE ACCESS ADVANCE PUBLICATION
    Coronary computed tomography angiography (CCTA) is the most commonly used modality for noninvasive plaque imaging in clinical settings. Characteristics of rupture-prone vulnerable plaques include positive remodeling, low attenuation, and napkin-ring sign in CCTA. About 60% of all vulnerable plaques have these characteristics, and these coronary lesions often result in plaque rupture. Identification of such groupings of coronary artery characteristics has been used to predict cardiovascular events.
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  • Yukinori Tomita, Ichiro Nakae, Hideki Hayashi, Tomoya Ozawa, Minoru Ho ...
    Article ID: 17-00026
    [Advance publication] Released: November 17, 2017
    JOURNALS FREE ACCESS ADVANCE PUBLICATION
    Purpose: “Heart Function View (HFV)” is a software that performs phase analysis as well as functional assessment of the left ventricle (LV) using myocardial perfusion single photon emission computed tomography (SPECT) (MPS). Phase analysis-derived phase standard deviation (PhSD) and histogram bandwidth (PhHB) are good indices for detecting LV dyssyncrony. We aimed to examine whether PhHB and/or PhSD (PhHB/PhSD) are useful clinical indicators that reflect the severity of heart failure (HF) in comparison with the LV ejection fraction (EF).
    Methods: Patients underwent 99mTc-tetrofosmin quantitative gated MPS including treadmill exercise. In HFV analyses, patients with induced ischemia were excluded. Phase and time-volume curve analyses were performed using HFV (n=66).
    Results: PhHB/PhSD correlated with LV end-diastolic volume (EDV), end-systolic volume (ESV), the first-third filling fraction (1/3FF), and peak filling rate (PFR) as well as echocardiography tissue Doppler-derived E/e’ as hemodynamic parameters of HF severity. LVEF also correlated with these hemodynamic parameters, except for 1/3FF. PhHB/PhSD positively correlated with log BNP as a neurohumoral marker of HF severity. LVEF negatively correlated with log BNP. PhHB/PhSD negatively correlated with exercise capacity as physiological indicators of HF severity, whereas LVEF did not. PhHB/PhSD were significantly greater in patients receiving cardiac resynchronization therapy (CRT, n=6) than in non-CRT patients (n=66), whereas LVEF were lower.
    Conclusion: PhHB/PhSD, similar to LVEF, are useful clinical indicators for evaluating HF severity. However, the clinical significance of LVEF and PhHB/PhSD differ. Thus, a phase analysis may additively offer useful information for the management of HF.
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