CIRCULATION CONTROL
Print ISSN : 0389-1844
Volume 32, Issue 3
Displaying 1-2 of 2 articles from this issue
original articles
  • Ryohei Kudo, Takashi Horiguchi, Toshiaki Nishikawa
    Article type: original articles
    2011 Volume 32 Issue 3 Pages 172-180
    Published: 2011
    Released on J-STAGE: May 31, 2013
    JOURNAL FREE ACCESS
    Clonidine, an α2-agonist, increases urine output and electrolyte excretion, and reduces the dose requirement of vasodilator for induced hypotension. We examined whether oral clonidine would provide these effects during hypotensive anesthesia.
    Twenty patients randomly received oral clonidine either 5μg/kg(clonidine group, n=10), or none(control group, n=10). General anesthesia was maintained with isoflurane and 67% N2O. During hypotensive period, mean arterial pressure(MAP) was kept at 50-60 mmHg. Urine output, urine osmolality, urinary excretion of electrolytes, and plasma ADH level were examined.
    Urine output and absolute urinary excretion of potassium were greater during the first 30 minutes of hypotensive period in the clonidine group than the control group. Five patients in the control group and one in the clonidine group had no urine output during the hypotensive period(p<0.05). Absolute urinary excretion of sodium and potassium increased in the control group after MAP recovered. However, plasma ADH levels did not change over time in both groups, and were similar between groups. No difference was found between the two groups in the dose requirement of nicardipine during hypotensive period.
    Oral preanesthetic medication of clonidine 5μg/kg provided a diuretic effect during hypotensive anesthesia.
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