Drug Metabolism and Pharmacokinetics

A Proposal of a Pharmacokinetic/pharmacodynamic (PK/PD) Index Map for Selecting an Optimal PK/PD Index from Conventional Indices (AUC/MIC, C_max/MIC, and TAM) for Antibiotics Yoshiaki KITAMURA, Kenta YOSHIDA, Makiko KUSAMA, Yuichi SUGIYAMA
Ethnic Differences in ATP-binding Cassette Transporter, Sub-family G, Member 2 (ABCG2/BCRP): Genotype Combinations and Estimated Functions Masayuki SAKIYAMA, Hirotaka MATSUO, Yuzo TAKADA, Takahiro NAKAMURA, Akiyoshi NAKAYAMA, Tappei TAKADA, Shin-ichiro KITAJIRI, Kenji WAKAI, Hiroshi SUZUKI, Nariyoshi SHINOMIYA
CYP-dependent Metabolism of Antitumor Pyrazolo[3,4-d]pyrimidine Derivatives Is Characterized by an Oxidative Dechlorination Reaction Claudio ZAMPERINI, Elena DREASSI, Giulia VIGNAROLI, Marco RADI, Stefania DRAGONI, Silvia SCHENONE, Francesca MUSUMECI, Massimo VALOTI, Riccarda ANTIOCHIA, Maurizio BOTTA
Human Nitrilase-like Protein Does Not Catalyze the Hydrolysis of Vildagliptin Mitsutoshi ASAKURA, Masataka NAKANO, Kohei HAYASHIDA, Hideaki FUJII, Miki NAKAJIMA, Koichiro ATSUDA, Tomoo ITOH, Ryoichi FUJIWARA