Emergency surgery for patients with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection should be avoided if possible because of increased risks of postoperative complications in patients and infection of medical staff members. We experienced a case of duodenal ulcer perforation that developed after SARS-CoV-2 infection. A 63-year-old man visited our hospital because of tiredness, and SARS-CoV-2 infection was confirmed. His general condition was good and followed up. The next day, he returned to the hospital because of abdominal pain and vomiting. Although his SARS-CoV-2 infection symptoms were mild, he was admitted to the hospital with a diagnosis of acute renal failure due to dehydration. An upper gastrointestinal perforation was revealed by computed tomography performed at the time of admission. Conservative therapy was selected because the abdominal symptoms were localized and inflammatory reaction was mild. However, laparotomy lavage drainage and gastrojejunos- tomy were needed because it worsened to generalized peritonitis. Despite adequate drainage and concomitant use of antibiotic therapy, multiple intra-abdominal abscesses formed. Additional drainage was required, and a long time was required for improvement of the inflammation. For patients with SARS-CoV-2 infection, the appropriate timing of emergency surgery, surgical procedures, and perioperative management is important to reduce complications.
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