Herein, we report the clinical statistical data of 2,313 patients who underwent microscopic laryngeal surgery at the Osaka Voice Center over the last 18 years. There were 1,074 cases of vocal fold polyps, 244 cases of vocal fold cysts, 211 cases of vocal fold paralysis, 190 cases of vocal nodules, 164 cases of Reinke's edema of the vocal folds, and 156 cases of laryngeal papilloma. By gender, the patients comprised 1,230 women (53.3%) and 1,083 men (46.8%). The youngest was 11 years old, the oldest was 89 years old, and the average age was 47.5 years. We also propose to report other data, including the occupational characteristics and reoperation rates.

　　As compared to previous reports, the percentage of women was higher, the percentage of patients with malignant tumors tended to be lower, and the percentage of cases with vocal fold cysts was higher. It is thought that the differences could possibly be attributable to the differences in the characteristics of the medical facilities included to collate the data, that is core regional hospitals in previous reports versus university hospital in our present report.

　　Based on these results, we discuss the indications for microscopic laryngeal surgery in each disease.

　　Nasal packing is commonly used to control bleeding and has the effect of a wet dressing following endoscopic sinus surgery (ESS). From the 2000's, calcium alginate dressings have been used to pack the middle meatus following ESS. Calcium alginate is a flocculent non-absorbable packing that shows a potent hemostatic effect, and acts as a wet dressing by absorbing and gelling the wound exudate. Until recently, Sorbsan^® (calcium alginate) was commonly used in Japan for postoperative nasal dressing. Unfortunately, sale of Sorbsan^® was discontinued in 2020, and we started collaborating the same year with Zuiko Medical corporation (Osaka, Japan.) for developing the new calcium alginate material Plus moist HS-W^®, and this product was launched in the market in Japan in 2022. Plus moist HS-W^® can be washed out of the nasal cavity by self saline irrigation as it is easily gellable and dispersible. The remnant gel can be easily removed using only suction tube. Satisfactory middle meatus epithelization has been reported to be observed following removal of Plus moist HS-W^®. Plus moist HS-W^® offers promise for use as a standard material for post operative nasal dressing.

　　Liquid biopsy is a remarkable and useful tool for detecting biomarkers in patients with various cancers. It has the potential to allow comprehensive evaluation of tumors, not only for predicting the diagnosis and prognosis before the start of treatment, but also for monitoring during treatment. Circulating tumor cells (CTCs) and circulating extracellular nucleic acids (cell-freeDNA; cfDNA)/circulating tumor DNA (ctDNA) that are shed from tumor tissues into the bloodstream are the targets of liquid biopsy. In this report, we would like to suggest that liquid biopsy might be a very useful tool for optimization and personalization of cancer treatment.