Dravet syndrome (DS) is an epilepsy syndrome characterized by seizures triggered by increases in body temperature as a result of fever or bathing or visual stimuli, such as lights or shapes ; these seizures are easily superimposable, intractable, and refractory to drug treatment. In patients with DS, perioperative seizure control is a focus of management. Here, we report our experience providing anesthetic management using remimazolam (RMZ) during dental treatment in a pediatric patient with DS. A 3-year and 5-month-old girl (weight, 13.8 kg ; height, 90 cm) had experienced multiple convulsive seizures since the age of 3 months and had been diagnosed as having DS based on genetic testing at 1 year of age. She had been treated with antiepileptic drugs but had also been occasionally admitted for emergency treatment because of convulsive seizures. For the planned dental treatment, slow induction with nitrous oxide, oxygen, and sevoflurane was performed and a venous route was secured. Oral intubation was performed after the administration of RMZ, remifentanil, and rocuronium. Anesthesia was maintained with air, oxygen, RMZ, and remifentanil. The patient’s intraoperative temperature and other vital signs were stable, and the prescribed dental treatment was completed. No fever or seizures were observed during the perioperative period, and she was allowed to go home after confirming the absence of any abnormalities in her recovery. RMZ is a short-acting benzodiazepine that may be useful for the anesthetic management of pediatric patients with DS because of its potential to prevent seizures.
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