Nippon Ishinkin Gakkai Zasshi
Online ISSN : 1882-0476
Print ISSN : 0916-4804
ISSN-L : 0916-4804
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Volume 48, Issue 3
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Short Report
  • Antifungal Potential of Disulfiram
    Seema Khan, Smita Singhal, Tarun Mathur, Dilip J. Upadhyay, Ashok Ratt ...
    2007 Volume 48 Issue 3 Pages 109-113
    Published: 2007
    Released on J-STAGE: November 21, 2007
    DOIhttps://doi.org/10.3314/jjmm.48.109
    JOURNAL FREE ACCESS
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    Disulfiram, an alcohol antagonistic drug has been on the market since 1949 with 80% bioavailability and an established safety profile. Recently it has been reported as a P-glycoprotein efflux pump modulator. Herein we report its antifungal potential. The MIC50 and MIC90 of disulfiram for yeast isolates is 4 and 8 μg/ml, respectively, and the MIC range is 1-16 μg/ml for both fluconazole sensitive and resistant strains. Interestingly, disulfiram also showed fungicidal activity on Aspergillus spp. with MIC50 and MIC90 of 2 and 8 μg/ml, respectively.
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