We report a case of metachronous quadruple cancer (gastric cancer, laryngeal cancer, colon cancer, and hepatocellular carcinoma) in a 76-year-old man. He had undergone surgery for gastric cancer in 1998 and radiotherapy for laryngeal cancer (Stage I) in 2004. A liver tumor was detected on computed tomography in 2005. A partial hepatectomy was performed in 2005. Then, in 2007 early ascending colon cancer was detected on colonoscopy ; endoscopic mucosal resection was performed.
Pathologically, the gastric cancer was a signet ring cell carcinoma with no submucosal invasion, T1, N0, and Stage I ; the hepatic cancer was moderately differentiated hepatocellular carcinoma, T2, N0, and Stage II ; the colonic cancer was well differentiated adenocarcinoma focally invading the submucosa, ly0, v0, and Stage I.
As the number of patients with multiple primary cancers is increasing. Cancer patients should be carefully examined given the possibility of multiple cancers.
View full abstract