The poultry industry is always at a risk due to high feed prices and frequent disease outbreaks. A global trend of using Antibiotic Growth Promoters (AGPs) for prophylaxis, improvement production, and enhanced growth have entered the poultry industry. Being banned in European countries, the AGPs are still extensively being used in South Asian’s poultry industry which has higher bacterial infections as compared to the European countries. Zinc bacitracin, an AGP, at sub-therapeutic concentration has shown advantageous results in poultry. In this study zinc bacitracin was made in CASVAB University of Balochistan labs and applied for the trial. In this study birds were distributed in three groups, group 1 used feed with no feed additive, group 2 used feed with 20 mg zinc bacitracin/kg and group 3 used 40 mg zinc bacitracin/kg in feed as feed additive. Body weight gain was observed as 513.7 grams (g) as compare to control group of birds which was 424.3 (g), which is highly significant and significant with group 2. Final body weight was observed 1250.1 (g) in group 3 significant with group 2 observed 1200.0 (g) and highly significant with group 3 which was 1100.2 (g). Mortality rate in group 3 was observed 1.8 which is highly significant P ≤ 0.05 with group 3 and significant with group 2. We also observed significant result in group 3 as compare to group 2 and 1, regarding to blood leukogram, hemogram and various serum chemistry attributes.

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In domestic cats, feline coronavirus (FCoV) infection is widespread, and its outcomes range from no signs to severe or potentially fatal disease. This study investigated the prevalence of infection and associated factors in a population of 277 owned cats in Thailand. The overall proportion of FCoV infections was 45.8%, with positive detections observed for all sample types. The positivity rates were 60.6% for rectal swabs, 51.3% for body fluids, and 11.1% for EDTA blood samples. Although the positive rate was slightly higher in males and more common in younger cats, neither difference was statistically significant. Mathematical modeling revealed a significant association between FCoV infection and the sampling period, with the highest positivity observed in April and June. Through S gene sequencing, positive samples from rectal swabs and body fluids [feline infectious peritonitis (FIP)-cats] were identified as FCoV genotype I. All rectal swab samples had a methionine codon at position 1058 of the S gene, and 62.5% of body fluid samples exhibited a notable substitution (M1058L). Additionally, analysis of the S1/S2 cleavage motif revealed that most FCoV-positive samples contained a polybasic R-R-S/A-R-R-S recognition motif. Notably, 37.5% of rectal swabs exhibited a mutation at the P1 residue (arginine to serine) and 14.3% of FIP-suspected cats exhibited a mutation at the P4 residue (arginine to glycine). These findings contribute to our understanding of the epidemiology of FCoV and its behavior in infected cats. Such insights are crucial for developing effective diagnostics, understanding the FCoV transmission dynamics, and informing potential control strategies.

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A 3-year-old castrated male cat was presented with lethargy, anorexia, and melena. A complete blood count revealed regenerative anemia. Abdominal ultrasonography revealed a layer-disrupted intestinal mass at the ileocecal junction. Fine needle aspiration performed on the mass revealed large lymphocytes, suggesting lymphoma. The patient was treated with CHOP-based chemotherapy but admitted for emergency care with vomiting and depression during the CHOP protocol. Abdominal ultrasonography suggested annular intestinal stricture at the site of lymphoma. The patient underwent ileocecectomy, which resolved the small intestinal obstruction. Histopathologic examination of the resected specimen demonstrated transmural enterotyphilitis with prominent fibrosis. The patient remained stable without relapse. To our knowledge, this is the first case of intestinal stricture occurring during chemotherapy for feline high-grade intestinal lymphoma.

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