Correlations between serum fatty acid composition (weight%) and leptin, BMI, triglyceride (TG), total cholesterol (TC), HDL cholesterol (HDLc), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were analyzed in sixty one male (41-80 years old) and twenty three female (52-79 years old) subjects without cardiovascular disease or diabetes meritus. Statistically significant negative correlations were found between nervonic acid (C24:1:n-9) and leptin, BMI and TG. Significant positive correlations were found between lauric acid (C12:0), myristic acid (C14:0), palmitic acid (C16:0), γ-linolenic acid (C18:3:n-6) and total saturated fatty acids (Σ SF) in female. A significantly negative correlation between linoleic acid and systolic blood pressure, and significantly positive correlations between eicosapentaenoic acid (EPA, C20:5:n-3) or dexahexaenoic acid (DHA, C22:6:n-3) and systolic blood pressure were found in male subjects.
In conclusion, serum nervonic acid could be a predictor of leptin status, obesity and hypertriglyceridemia.
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