In the hippocampal CA1 area, repetitive correlated spiking of pre- and postsynaptic neurons can induce LTP and LTD, depending on the timing of the pre- and postsynaptic excitation (Spike timing Dependent Plasticity). To investigate the information processing on the dendrite of a single neuron during the induction of STDP in the hippocampal CA1 area, model simulation was performed using NEORON simulator. As a result, (1) the location dependency of amplifying synapse, (2) the effect of gating a back-propagating action potential to distal dendrites by inputs on the proximal dendrite, and (3) the effect of inhibitory input to the induction of STDP were clarified.
View full abstract