The present study was designed to evaluate the amount of sweating as a result of moderate exercise training on chronic hemodialysis patients.
1. Six hemodialysis patients who were receiving exercise training according to our walking and jogging program, and six other patients who were not taking exercise training were examined. When their increased weight since last dialysis was compared, no significant difference could be recognized, between the two groups nor was there any trace of difference in the amount of increased weight.
2. Four comparatively stable male chronic hemodialysis patients who were undergoing this exercise training program were evaluated. These patients were weighed before and after exercise training to determine the amount of sweating. During exercise training, no significant difference in the amount of sweating was recognized whether it was performed on the day before hemodialysis or immediately after hemodialysis and these two groups showed the same amount of sweating. A positive correlation could be observed between the amount of sweating and the maximal oxygen intake (VO₂max) during exercise training. As VO₂max increased, so did the amount of sweating. A more positive correlation was also observed between the intensity of exercise and the enegy consumed among patients undegoing intensive exercise. As in the case of healthy subjects, chronic hemodialysis patients can expect to improve their exercise durability, and gain more ability to perspire to an acceptable degree through this exercise training. Furthermore, easier water control upon loss of water can be expected because of sweating.

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In an attempt to define the problems of dialysis treatment in patients with SLE, we studied 17 patients with lupus nephritis who underwent dialysis at Kyorin University Hospital and affiliated hospitals. The patients could be divided into two groups according to the clinical course before and after the beginning of dialysis.
Seven patients progressed to end-stage renal failure rapidly, mostly within 4 months after the appearance of proteinuria, accompanied by active extrarenal symptoms and immunologic activity. Four of them died of uremia, heart failure or gastrointestinal bleeding and 3 recovered renal function and discontinued dialysis. All these patients required the administration of large doses of steroid to control SLE activity. The other 10 patients progressed to end-stage renal failure slowly and after the beginning of dialysis both clinical and immunologic activity improved with long-term hemodialysis despite the withdrawal of steroids.
From these experiences, we proposed guidelines for the dialysis treatment of SLE.

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Two cases of familial hypercholesterolemia were treated with sorbent beads, LA01 (Kanegafuchi Chemical Industrial Co., Ltd, Osaka). The rate of reduction of the plasma cholesterol level was around 50% after treatment with 3, 000ml of plasma. HDL cholesterol, total protein and immunoglobulin did not show any significant change during the operation. About a 50% decrease in complement C4 was observed, probably caused by absorption. LA01 is a potent specific sorbent of LDL cholesterol for plasmapheretic treatment of familial hypercholesterolemia.

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In a previous study, we measured the amount of potassium (K) removed by hemodialysis (HD) as well as the erythrocyte K (Rk) concentration before and after HD. The data showed that in some chronically hemodialyzed patients, K entered into the intracellular space during HD, while in others, K was removed from the intracellular fluid by HD. To determine the cause of K movement by HD, we studied the interaction between the change in Rk concentration and arterial blood pH in 12 hemodialyzed patients. The Rk concentration was 102.1±3.7mEq/l. cell before HD and 94.4±0.58mEq/l cell in normal subjects. There was no significant difference between them.
In three out of the 12 cases, the Rk concentration rose during HD, but in 6 cases it fell during HD. In the former cases, the arterial blood pH was 7.229±0.008, in the latter, it was 7.336±0.016. A significant linear correlation was obtained between the change in Rk concentration caused by HD and the arterial blood pH before HD (y=0.084 x-7.30, r=0.74, p<0.01).
In patients with acidosis before HD, the Rk concentration rose. Therefore we concluded that the blood pH might affect the amount of K removed from the cells by HD.

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