This study examined the factors that influence disaster-nursing practices among clinical nurses, focusing on regional differences between Kanto and Tohoku. Furthermore, this study aimed to clarify issues related to disaster-nursing practices. In this cross-sectional study, a web-based survey was administered to nurses affiliated with disaster-based hospitals in Kanto and Tohoku. The survey items included (1) disaster preparedness behaviors, (2) disaster self-efficacy (disaster SE), (3) knowledge of disaster-nursing practices, and (4) open-ended statements regarding disaster-nursing practices. Descriptive statistics, propensity score matching, and multiple regression analysis with knowledge of disaster-nursing practices as the dependent variable were used. Free descriptions of the challenges of disaster-nursing practices were also analyzed. In total, 1,345 and 622 valid responses were obtained from Kanto and Tohoku, respectively. The number of respondents in both regions was adjusted to 574 by matching. The responses that were favorable for disaster-nursing practices and significantly higher in Tohoku than in Kanto were “understanding of CSCATTT for disaster preparedness,” “understanding of manuals,” “dealing with infected patients,” “disaster SE,” and “pre- and postgraduate education.” Multiple regression analysis revealed that disaster preparedness behaviors, disaster SE, and postgraduate education were significant items in order of increasing standardized coefficients. In the content analysis of issues associated with disaster-nursing practices, 14 categories were extracted; the most frequent codes were “Insufficient practical education/training” and “Insufficient establishment of continuing education.” Disaster-nursing knowledge was influenced by disaster preparedness, disaster SE, and postgraduate education. Moreover, the knowledge gained from the disasters was used for awareness and education in Tohoku. These results suggest the need to strengthen continuous and practical education in disaster-nursing practices.
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