It is not known whether pregnant women with chronic hypertension (CH) develop preeclampsia (PE) more frequently than those with white coat hypertension (WCH). Therefore, we planned the following 2 studies: study 1 is a multicenter prospective observational study to distinguish WCH and CH, in (A) pregnant women with suspected hypertension with blood pressure measured in a clinical setting, and who had not been diagnosed with hypertension prior to the current pregnancy, and (B) pregnant women with a previous diagnosis of hypertension, but who have not received an accurate diagnosis specifying whether they have CH or WCH; study 2 is a multicenter retrospective cohort study, which will start after the recruitment of subjects in study 1, to compare the incidences of PE and gestational hypertension (GH) in women with WCH or CH. Here, we described a protocol for a prospective multicenter cohort study (JP-WCH study; UMIN study ID: UMIN000032790).
Aim: Several devices are used for balloon tamponade. In Japan, metreurynters are widely used for cervical ripening; however, there is little evidence for their use in hemostatic uterine balloon tamponade. This study aimed to assess the non-inferiority of metreurynters as the balloon device for obstetric hemorrhage.
Methods: Medical charts of all patients with obstetric hemorrhage of more than 1,000 ml who underwent balloon tamponade with metreurynters were retrospectively reviewed for five years at a tertiary referral university hospital.
Results: A total of 89 uterine balloon tamponade cases were identified from medical records. Of these, 66 cases involved term postpartum hemorrhage (PPH) within 24 h after delivery (PPH group) and 23 involved other types of cases (other group), including cesarean scar pregnancy, cervical pregnancy, retained placenta, and others. In the PPH group, the average hemostasis rate was 93.9%, whereas the rate was 91.3% in the other group. Seven cases failed to achieve hemostasis with balloon tamponade only and required additional treatment. There were no adverse events related to balloon tamponade using metreurynters.
Conclusions: Metreurynters used for balloon tamponade were non-inferior to Bakri balloons in hemostasis and complication rates, suggesting they are effective and appropriate for the management of obstetrical hemorrhage.
Aim: This study aimed to identify risk factors for bleeding complications of postoperative prophylactic anticoagulation after cesarean section in preeclampsia cases.
Methods: A total of 68 cases of preeclampsia or superimposed preeclampsia at a tertiary perinatal center in Tokyo between 2012 and 2017 were recruited for this study. Bleeding complications were defined as subcutaneous, subfascial, or intraperitoneal hematoma detected by ultrasonography or computed tomography. Associations of clinical and laboratory data with bleeding complications were assessed by univariate and multivariate analyses.
Results: Bleeding complications were recorded in nine cases: subcutaneous hematoma in four cases, subfascial hematoma in four cases, and intraperitoneal hematoma in one case. Univariate analysis revealed preoperative platelet count and 24-h urine protein level to be associated with bleeding complications. Moreover, multivariate logistic regression analysis revealed preoperative platelet count (odds ratio, 0.867; 95% confidential interval, 0.756–0.994; P=0.04) and 24-h urine protein level (odds ratio, 1.498; 95% confidential interval, 1.031–2.176; P=0.03) to be independent risk factors for bleeding complications.
Conclusion: Preoperative platelet count and 24-h urine protein level may help to identify patients at increased risk for bleeding complications.