Kobunshi
Online ISSN : 2185-9825
Print ISSN : 0454-1138
ISSN-L : 0454-1138
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Volume 56, Issue 9
Displaying 1-20 of 20 articles from this issue
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  • Hot Topics
    2007 Volume 56 Issue 9 Pages 732-734
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.732
    JOURNAL FREE ACCESS
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  • Biomaterial Era-Realization of Dreams and Challenges-
    Takehisa MATSUDA
    2007 Volume 56 Issue 9 Pages 735
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.735
    JOURNAL FREE ACCESS
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  • Design of Intelligent Polymeric Micelles for Advanced Medicine
    Nobuhiro NISHIYAMA, Kazunori KATAOKA
    2007 Volume 56 Issue 9 Pages 736-739
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.736
    JOURNAL FREE ACCESS
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    Recently, medical applications of nanotechnology have received much attention. Particularly, advances in polymer chemistry have significantly contributed to this field. Here, we review polymeric micelles for drug and gene delivery. Polymeric micelles are promising drug carriers, of which the critical parameters such as the size, drug loading and release can be controlled by engineering the structures of constituent block copolymers. Nano-engineering of functional polymers allows the development of polymeric micelles with integrated intelligent functions such as the environment-sensitivity and targetability. Also, external stimuli such as light can be used for the activation of polymeric micelles. Intelligent polymeric micelles are expected to be nanotechnology-based carrier systems for clinical use.
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  • Clinical Development of Bio-Artificial Tissues by Using Living Cells
    Ken-ichiro HATA
    2007 Volume 56 Issue 9 Pages 740-744
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.740
    JOURNAL FREE ACCESS
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    Many clinical report described the application using bio-artificial tissues with living cells were published. Skin and joint cartilage were targeted for those kinds of strategy. Three different types of artificial skin were established and commercialized in US, EU and Asian nation except Japan. Two types of cultured cartilage were also commercialized. For the development of next artificial tissues, improved materials are needed as the scaffold of the inoculated cells. Moreover, those materials should have the potentials for the extracelluer matrix after transplantation.
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  • Next Generation Left Ventricular Assist Device: EVAHEART
    Kenji YAMAZAKI
    2007 Volume 56 Issue 9 Pages 745-748
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.745
    JOURNAL FREE ACCESS
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    EVAHEART is an implantable centrifugal blood pump for long-term circulatory assistance. Japanese clinical feasibility study has been conducted since May 2005. Inclusion criteria were; end-stage irreversible heart failure of NYHA class IV, eligible for heart transplantation, inotropic dependent, age from 20 to 60 years old. Three dilated cardiomyopathy patients have been enrolled for feasibility study and supported for 821 +, 761 +, 757 + days, respectively, and on going. Though the pump speed was fixed at constant speed, the pump flow rate was complete pulsatile pattern. NYHA class improved to I. All three patients discharged from hospitals on device, enjoy daily life at home. Furthermore, the first patient came back to work. Pivotal study (4 clinical sites, 16 subjects) started on June 2006. Nine patients were enrolled as of today. One patient died due to cerebral bleeding on POD 62. Eight patients have been supported for 405+, 332+, 325+, 269+, 155+, 148+, 130+, 8+ days, respectively (on going). EVAHEART provided complete pulsatile high flow circulatory support and satisfactory results have been obtained in Japanese clinical study.
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  • Trends and New Approaches in the Research and Development of Artificial Lungs
    Eisuke TATSUMI
    2007 Volume 56 Issue 9 Pages 749-753
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.749
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    This article describes the progress of artificial lungs, centering on the historical context and the trends in its research and development. While the performance of artificial lungs for open-heart surgery has become sufficient, the increase in the number of its uses in assisted circulation such as extracorporeal membrane oxygenation (ECMO) and percutaneous cardiopulmonary support (PCPS) cases is showing significant growth. Along with such clinical trends, research and development towards next generation artificial lungs are active in the field of assisted circulation, focusing upon safe long-term use. Approaches include preventing plasma leak by developing durable gas-exchange membranes, enhancing hemocompatibility by heparin-bonding surface treatment, developing a novel device by integrating the oxygenator with the blood pump, and developing an implantable artificial lungs such as intravenous oxygenator. The next-generation artificial lungs will not only benefit a multitude of patients but represent an important target with a prospect for expansion of the artificial lung's market from the standpoint of the enterprises. In future, further expansion of research and development in this field as well as progress in practical and clinical applications of innovative devices are expected.
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  • Synthetic Absorbable Sutures for Leading-edge Surgery
    Tomohiko ASAHARA
    2007 Volume 56 Issue 9 Pages 754-757
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.754
    JOURNAL FREE ACCESS
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    Design concept and key role of synthetic absorbable suture are reviewed in terms of mechanical and material life after surgery. Also, mentioned how highly-fine handling properties are developed in the leading braided/monofilament suture products.
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  • Present Situation of Medical Devices Supported by Polymeric Materials
    Kazuhisa SENSHU
    2007 Volume 56 Issue 9 Pages 758-761
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.758
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    Currently, various kinds of medical devices are used in hospitals not only for general medical treatment and diagnosis but also for advanced medical treatment. Most medical devices are made from polymeric materials and used as disposable products. Development of disposable medical device was started from injection syringes in 1963, and went to blood collection bags and transfusion bags. Furthermore, the research and development of disposable medical devices have been spread to artificial organ like hollow fiber dialyzers, pump oxygenators and catheters for medical treatment. Recently, polymeric materials are applied for implantable medical devices such as artificial vessels and pacemaker leads. One of the greatest reasons for the progress of medical devices is the growth of polymer science. The processing technology of multilayer sheet enables to make sterilized transparent plastic bags. The polymerization technology of various thermoplastic elastomer such as polyethylene, polypropylene, poly(vinyl chloride), and styrene, and the blend technology of polymer alloy make the production of general medical devices possible. However, the materials used for medical devices are usually diverted from common engineering polymers, which were not designed only for the medical field. It is strongly desired the development of polymeric materials with biocompatibility and useful physical characteristics for medical devices.
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  • [title in Japanese]
    2007 Volume 56 Issue 9 Pages 762
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.762
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    2007 Volume 56 Issue 9 Pages 762a
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.762a
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    2007 Volume 56 Issue 9 Pages 762b
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.762b
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    2007 Volume 56 Issue 9 Pages 762c
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.762c
    JOURNAL FREE ACCESS
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  • Development of UHMWPE-Vitamin E Knee Components
    An Achievement of Problem Oriented Research
    Naohide TOMITA
    2007 Volume 56 Issue 9 Pages 763
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.763
    JOURNAL FREE ACCESS
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  • Medical Adhesive“LYDEX”
    Suonz-Hvu HYON, Naoki NAKAJIMA, Hajime SUGAI
    2007 Volume 56 Issue 9 Pages 764
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.764
    JOURNAL FREE ACCESS
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  • Dental Polymeric Materials beyond Metal and Ceramics
    Junji TAGAMI
    2007 Volume 56 Issue 9 Pages 765
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.765
    JOURNAL FREE ACCESS
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  • Application for Ophthalmic Solution of Stimuli-Responsive Polymer
    Fumitaka TASAKA
    2007 Volume 56 Issue 9 Pages 766
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.766
    JOURNAL FREE ACCESS
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  • Virus and Prion Removal Filter PlanovaTM
    Tetsuo SATO
    2007 Volume 56 Issue 9 Pages 767
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.767
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Akio YAMAMOTO
    2007 Volume 56 Issue 9 Pages 768-774
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.768
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Tadahiro UEMURA, Takao SASAKI
    2007 Volume 56 Issue 9 Pages 775-779
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.775
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Naoki YOSHIMOTO
    2007 Volume 56 Issue 9 Pages 780
    Published: September 01, 2007
    Released on J-STAGE: October 14, 2011
    DOIhttps://doi.org/10.1295/kobunshi.56.780
    JOURNAL FREE ACCESS
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