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Shuichi Hayashi, Satoshi Umemura, Shin-ichi Tohyama, Tadashi Shindo, M ...
1995 Volume 27 Issue Supplement2 Pages
5-10
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Ryo Kataoka, Kenjirou Kikuchi, Stephen M. Lanier
1995 Volume 27 Issue Supplement2 Pages
11-15
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Huang-Tian Yang, Ikuo Norota, Yi Zhu, Masao Endoh
1995 Volume 27 Issue Supplement2 Pages
16-19
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Hiroshi Jino, Hachiro Usui, Shinji Temma, Shohei Nakamura, Yohei Nakat ...
1995 Volume 27 Issue Supplement2 Pages
20-23
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Miho Kasama, Yasuyuki Furukawa, Yuji Hoyano, Shigetoshi Chiba
1995 Volume 27 Issue Supplement2 Pages
24-26
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Haruhiko Abe, Akio Kuroiwa
1995 Volume 27 Issue Supplement2 Pages
27-31
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Makoto Sonoda, Katsu Takenaka, Fumiyoshi Watanabe, Tsutomu Igarashi, M ...
1995 Volume 27 Issue Supplement2 Pages
32-34
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Toshihiko Ishimitsu, Shigeru Yagi, Akio Fujimura, Akio Ebihara, Yasuro ...
1995 Volume 27 Issue Supplement2 Pages
35-40
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Takao Noshiro, Hiroyoshi Akama, Toshiya Watanabe, Kazumasa Shimizu, Ta ...
1995 Volume 27 Issue Supplement2 Pages
41-44
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Ken-ichi Yasunari, Masakazu Kohno, Hiroaki Kano, Mieko Minami, Takao H ...
1995 Volume 27 Issue Supplement2 Pages
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Fumi Katoh, Kazuo Kitamura, Yoshitaka Yamamoto, Kenji Kangawa, Tanenao ...
1995 Volume 27 Issue Supplement2 Pages
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Toshihiko Ishimitsu, Toshio Nishikimi, Yoshihiko Saito, Kazuo Kitamura ...
1995 Volume 27 Issue Supplement2 Pages
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Hirotoshi Kitagawa, Tsuyoshi Akiyama, Toji Yamazaki
1995 Volume 27 Issue Supplement2 Pages
56-59
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Kiyoji Asano, Hiroyasu Ito, Shinya Minatoguchi, Yoko Imai, Masatoshi K ...
1995 Volume 27 Issue Supplement2 Pages
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Di-Sheng Men, Aiko Matsui, Yoichiro Matsui, Jie Lin, Hirofumi Osada, T ...
1995 Volume 27 Issue Supplement2 Pages
64-68
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Takuzo Hano, Masato Mizukoshi, Akira Baba, Osamu Satani, Masahiko Shio ...
1995 Volume 27 Issue Supplement2 Pages
69-72
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Kazushi Tsuda, Ichiro Nishio, Yoshiaki Masuyama, Menek Goldstein
1995 Volume 27 Issue Supplement2 Pages
73-77
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Kenji Kangawa, Naoto Minamino, Hisayuki Matsuo, Kazuo Kitamura, Tanena ...
1995 Volume 27 Issue Supplement2 Pages
78-85
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Michael Böhm
1995 Volume 27 Issue Supplement2 Pages
86-100
Published: May 25, 1995
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Alterations of receptor-G-protein-regulated adenylyl cyclase activity have been suggested to represent an important alteration leading to contractile dysfunction in the failing human heart. Recent experiments suggest that the β
1-adrenoceptor(β
1AR)density and mRNA levels are reduced, while β
2-adrenoceptors and stimulatory G-proteins are unchanged(mRNA and protein level). Functional assays demonstrated that the catalyst of the adenylyl cyclase is not different between failing and nonfailing myocardium. Inhibitory G-proteins are increased (pertussis toxin substrates, protein and mRNA) and correlate to the reduced inotropic effects of β-adrenoceptor agonists and of cAMP-PDE inhibitors. Gia-coupled m-cholinoceptors and A
1-adrenergic receptors are unchanged in density and affinity. Stimulation of these receptors resulted in an unchanged antiadrenergic effect on force of contraction. In conclusion, a downregulation of β
1AR and an increase of Gia have been observed as signal transduction alteration in failing human myocardium. These alterations are due to alterations of gene expression in the failing heart and are related to a defective regulation of force of contraction in heart failure.
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