Twenty five healthy subjects and 24 obese subjects were taken a normal meal and a high-fat meal, and the blood triglyceride (TG) concentration and intestinal alkaline phosphatase（IAP） activity of these subjects were measured before and after the meal.
  Comparing the normal-meal subjects and the high-fat meal subjects, it was found that the high-fat meal subjectgroup was higher than the normal-meal subject group in the TG concentration; 25.4％ for the healthy subjects and 31.8％ for the obese subjects (p < 0.01 in bothcases). In addition, it was found that the high-fat meal subject groupwas higher than the normal-meal subject group for the intestinal alkaline phosphatase (IAP) activity; 13.9％ in thehealthy subjects and 25.9％ in the obese subjects (p = 0.08 and 0.03, respectively).
  Regarding the IAP activity, some difference was found between A and B, A and O blood groups (p < 0.05) for the healthy subjects, and a significant difference was found between A and B, A and O, AB and B, AB and O blood groups for the obese subjects (p < 0.01).
  The correlation coefficient between the TG concentration and the IAP activity was the same value as 0.15 for A and AB, and 0.89 for B and O blood groups in the normal-meal subjects, and the same value as 0.46 for A and AB,and 0.91 for B and O blood groups in the high-fat meal subjects. In the subjects have taken the normal-meal and high-fat meal, B and O blood groups had a higher correlationship to the TG and IAP levels, than those of A and AB blood groups.
 Taken together, it was suggested that the increased IAP activity and the TG metabolism were strongly associatedwith each other in ABO blood group secretors. For the decreased abdominal circumference, TG and IAP values before and after eicosapentaenoic acid (EPA) administration, the B and/or O blood group secretors were remarkable compared with the non-secretor of B and the O blood groups.

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