Introduction: Diffuse idiopathic skeletal hyperostosis (DISH) -related fractures have a high frequency of delayed diagnosis and paralysis even if caused by low-energy trauma, which makes diagnosing vertebral fractures (VFs) with DISH challenging. This study compared the clinical and radiologic features of VFs with DISH.

Methods: This study included 252 patients (70 men and 182 women; mean age  standard deviation, 81.0  8.6 years) with VFs in this study. Patients were divided into two groups depending on DISH (group D) or not (group N). We measured the sex, age, body mass index, hemoglobin A1c, and bone mineral density. This study also measured the spinopelvic sagittal alignments, local angular motion, inflection point, number of VFs, intervertebral disk (IVD) injury, and signal changes on magnetic resonance image (MRI).

Results: The presence of DISH in VFs was identified in 104 patients (41.3%) (49/70 [70.0%] in men vs. 55/182 [30.2%] in women). Group D was related to male sex, older age, larger thoracic kyphosis, VF at lower lumbar lesion, number of VFs, IVD injury, inflection point at lower lumbar, local angular motion, diffuse low signals on T1 MRI, and high or diffuse low signals on T2 MRI on univariant analysis. Multiple logistic regression analysis showed that the predictive factors for DISH were male sex, angular motion, VF at lower lumbar lesion, IVD injury, inflection point at lower lumbar, and diffuse low signals on T1 MRI.

Conclusions: DISH was related to IVD injury, angular motion, and diffuse low signals on T1 MRI. In addition, VFs with DISH were more frequently found in men at the lower lumbar lesion than in women at thoracolumbar. When physicians detect these factors, attention should be given to VFs with DISH, and whole-spine computed tomography should be considered not to overlook the presence of DISH.

Background: Prolapsed lumbar intervertebral disc (IVD) is a prevalent spinal cause of low back pain associated with radicular pain. Platelet-rich plasma (PRP) has emerged as a potential alternative to epidural steroid injections. This review aimed to compare the efficacy of epidural PRP and epidural steroid injections in treating low back pain due to prolapsed lumbar IVD, assessed using a pain scale and Oswestry' s disability index (ODI).

Methods: A systematic search of 4 databases (PubMed, Scopus, ScienceDirect, and Cochrane Central Register of Controlled Trials) up to July 2024 for randomized controlled trials comparing epidural PRP with steroids. Risk of Bias 2 was used for bias assessment. Pain and ODI mean differences (MDs) were calculated using RevMan v5.4. Heterogeneity was measured using I², with random or fixed effects applied accordingly. The combined outcome progression of pain and ODI scores were computed using STATA/MP 17.0 software.

Results: Three trials (n = 132) were included. At 1 month, epidural steroid injections showed lower pain scores than PRP (standard MD = 1.04, 95% confidence interval [CI]: 0.63-1.46, p< 0.00001, I² = 0%). At 6 months, epidural PRP injection demonstrated greater pain relief (MD = −1.51, 95% CI: −1.98 to −1.05, p < 0.00001, I² = 0%) and lower ODI (MD = −9.71, 95% CI: −16.63 to −2.78, p = 0.006, I² = 75%). Epidural steroids showed significant worsening in pain score (1 vs 3 months, p = 0.001; 3 vs 6 months, p = 0.003).

Conclusions: Epidural PRP provides sustained and gradual improvement of pain and ODI for patients with prolapsed lumbar IVD over months of follow-up, while steroids provide initial relief at 1 month but are associated with worsening at later follow-ups.

Introduction: The geriatric nutritional risk index (GNRI) has emerged as a useful predictor of surgical risk and postoperative outcomes. This study aimed to explore the utility of GNRI as a semiquantitative tool for predicting systemic and local complications after multilevel thoracolumbar fusion surgery in older patients and to evaluate the broader implications of nutritional status on postoperative recovery and independence.

Methods: This multicenter study included 249 patients aged 65 years or older who underwent thoracolumbar fusion of at least four vertebrae. The nutrition-related risk grades were defined by the GNRI values, and the patients were divided into four groups: risk absent (GNRI > 98), low risk (GNRI 92 to ≤98), moderate risk (GNRI 82 to <92), and major risk (GNRI < 82). The occurrence of systemic complications, surgical site infection (SSI), length of stay in the hospital, place of discharge, and occurrence of proximal junctional kyphosis or failure (PJK/PJF) within 2 years after surgery were examined.

Results: The risk-absent group consisted of 165 patients, the low-risk group of 40, the moderate-risk group of 36, and the major-risk group of eight. The incidence of any systemic complications (p = 0.016), PJK/PJF (p < 0.001), and hospital stay (p = 0.028) significantly increased with worsening GNRI. Furthermore, the number of patients who were discharged home significantly decreased as GNRI worsened (p < 0.001). SSI occurred most frequently in the risk-absent group (4.2%).

Conclusions: The GNRI serves as a semiquantitative assessment tool that enables the identification of high-risk patients who may benefit from preoperative nutritional interventions.

Introduction: Low bone mineral density (BMD), a history of vertebral fractures (VFs), and steroid use are established risk factors for VFs. Additionally, age, nutritional status, muscle mass, and spinal sagittal alignment have been linked to osteoporosis and fractures. This study aims to investigate the risk factors contributing to new occurrences of VFs.

Methods: We included 597 patients with osteoporosis who visited our outpatient department and were available for follow-up 1 year after the visit. The following data were collected: age at examination, presence of secondary osteoporosis, body mass index, lumbar spine BMD, femoral neck BMD, number of VFs, grip strength, trunk muscle mass, controlling nutritional status (CONUT) score, sagittal vertical axis (SVA), pelvic tilt, pelvic incidence–lumbar lordosis, thoracic kyphosis on whole-spine standing radiography, and osteoporosis treatment status at baseline. Patients who had new VFs confirmed on whole-spine standing radiography at the 1-year follow-up visit were included in the group with new VF occurrence. We performed between-group comparisons of each parameter. Additionally, to identify risk factors for new VFs, we conducted a multivariate analysis using the presence of new VFs as the dependent variable.

Results: A total of 60 new VFs occurred during the 1-year period, representing 10.1% of the study population. When comparing the new VF incidence group with the non-incidence group, the CONUT score and SVA were significantly higher in the new VF incidence group. There were no significant differences between the 2 groups for the other variables. Multiple logistic regression analysis indicated that both a high CONUT score and SVA were independent risk factors for the occurrence of new VFs.

Conclusions: The 1-year incidence of new VFs was 10.1% among patients with osteoporosis, despite appropriate osteoporosis treatment. These patients also exhibited malnutrition and spinal sagittal malalignment at baseline. Our findings suggest that malnutrition and spinal sagittal malalignment may be independent risk factors for the occurrence of new VFs.

Introduction: We evaluated the effect of 3 high-angle cages on spinal alignment and clinical outcomes following posterior lumbar interbody fusion (PLIF).

Methods: A retrospective analysis was performed on 104 patients who underwent PLIF at the L4/5 level between January 2021 and August 2023. Patients were divided into 3 groups: 12° (L), 16° (M), and 22° (H) cage groups. Lumbar spine radiographs were taken preoperatively and one year postoperatively to assess slip rate (% slip), segmental lumbar lordosis (SLL), segmental intervertebral angle (SIA), lumbar lordosis (LL), pelvic incidence-LL, sagittal vertical axis (SVA), Japanese Orthopedic Association score, and lower back pain visual analog scale score. Bone union and cage subsidence rates were evaluated using computed tomography 6 months postoperatively. Statistical analyses were performed using either the Wilcoxon signed rank test, Kruskal–Wallis test, or z-test.

Results: Intragroup analysis showed significant improvements in local alignment, with notable SVA improvement in the H group. Intergroup comparisons revealed no significant differences in preoperative evaluation items. Postoperatively, the H group showed significantly greater improvements in SLL and SIA than the L group. Although no significant difference was observed in bone union, the cage subsidence rate was significantly higher in the H group than in other groups.

Conclusions: PLIF using high-angle cages (≥12°) significantly improved local alignment in all groups. The 22° cage showed greater improvements in SLL and SIA but a higher incidence of cage subsidence. No significant clinical differences were observed between groups. LL in the lower lumbar spine can be achieved relatively easily using a cage with a larger angle in PLIF. However, although a cage with a larger angle may be advantageous for lordosis formation, postoperative clinical outcomes do not differ; therefore, cage selection should consider the surgeon's skill and patient factors, such as the degree of preoperative lumbar disc degeneration, instability, and alignment.

Background: Symptomatic lumbar foraminal stenosis (LFS) occurs when the neuroforamen narrows, compressing the exiting spinal nerve, leading to symptoms such as radicular pain, paresthesias, and potentially weakness. Although cross-sectional imaging studies are used for diagnostic purposes, there is no clear consensus as to which grading system best evaluates LFS, predisposing to inconsistencies in care. This systematic review aimed to evaluate and compare existing published grading systems for LFS to identify (1) systems most used within the literature and (2) the most effective and reliable method for classifying anatomic severity and clinical symptom correlation.

Methods: This study is a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, analyzing available literature on grading systems for LFS, level of evidence IV. A comprehensive search of PubMed, Embase, and Cochrane Trials was conducted from inception through July 2024. Eligible studies were evaluated for methods, bias, sample size, patient demographics, imaging modalities, and grading systems. Bias was assessed using the Methodological Index for Non-Randomized Studies. Data were synthesized narratively and descriptively.

Results: The review included 35 studies, most using magnetic resonance imaging (88.6%). Seven grading systems have been identified. The original Lee et al. grading system was the most frequently used LFS grading system (69%), followed by Wildermuth et al. (14.3%). Notably, artificial intelligence (AI) grading systems were included in two studies (5.7%). Findings regarding symptom correlation were mixed.

Conclusions: The Lee et al. grading system remains the most used grading system for LFS in the literature and is reliable. Several small studies found an association between the Lee et al. system and clinical symptoms/treatment outcomes; however, this was not universally found. Further investigation is needed to validate the newer grading. The introduction of AI may offer promise for refining the diagnostic and clinical utility of published LFS grading systems.

Introduction: Delayed diagnosis and therapy initiation for pyogenic spondylitis can have severe and fatal consequences. Early diagnosis and intervention are crucial in the treatment of pyogenic spondylitis. This multicenter cross-sectional study with prospective case series aimed to identify factors influencing the time from symptom onset to the diagnosis of pyogenic spondylitis.

Methods: Patients hospitalized with pyogenic spondylitis between 2019 and 2023 were included. Patients were classified into 2 groups: the delayed diagnosis group (>30 days from the onset of initial symptoms to the diagnosis of pyogenic spondylitis) and the early diagnosis group (within 29 days). Risk factors for delayed diagnosis were analyzed.

Results: A total of 74 patients (42 men and 32 women; mean age: 70.2 years) from 5 institutions were included. Univariate analysis of risk factors for delayed diagnosis revealed that the significant risk factors included advanced age (p = 0.03), low white blood cell count (p < 0.01), low C-reactive protein level (p < 0.05), and semi-rigid spinal level, based on the spinal instability neoplastic score classification (p = 0.05). Multivariate analysis for delayed diagnosis showed that the location at the semi-rigid spinal level was a significant risk factor (p = 0.02). The vertebral bone destruction rate and abscess cavity index in the delayed diagnosis group were significantly higher than those in the early diagnosis group (p < 0.01 and p < 0.01, respectively).

Conclusions: Significant risk factors for delayed diagnosis of pyogenic spondylodiscitis include infection at the semi-rigid thoracic spinal level. Early diagnosis of spondylodiscitis is crucial because delayed diagnosis can lead to progressive bone destruction and the formation of large abscesses. Increased awareness of thoracic spinal infections, which can easily delay diagnosis, could help in the early diagnosis and treatment of pyogenic spondylodiscitis.

Objectives: Total disc replacement (TDR) using Mobi-C^® and Prestige LP^® was approved in Japan in 2017. To ensure effective surgical outcomes with TDR, the Japanese TDR guideline was established before its clinical use, and a registry system was developed to monitor the safety of early cases in Japan. This study assessed complications associated with TDR during the early post-approval period using this nationwide registry to evaluate the short-term safety of single-level TDR.

Methods: Data from the nationwide registry covering postoperative 2-year surveillance were analyzed for single-level TDR performed during the post-marketing surveillance period in Japan. The database included patient characteristics, surgical details, complications, and reoperations. Complication and reoperation rates were analyzed for the perioperative period during hospitalization and the postoperative period after discharge.

Results: In total, 332 patients were enrolled in this study, and 271 patients completed the 2-year follow-up (81.6%). Mobi-C^® and Prestige LP^® were used in 158 and 113 patients, respectively. Perioperative complications included hematoma (n = 3) and airway obstruction (n = 1). Three (1.1%) patients with hematoma underwent reoperation in the perioperative period during hospitalization. Overall, 20 (7.4%) patients experienced complications after discharge up to 2 years postoperatively, including recurrences of neurological symptoms (n = 9), implant migration (n = 2), implant subsidence (n = 7), and others (n = 3). Two (0.7%) patients who experienced a recurrence of neurological symptoms underwent additional posterior foraminotomy within 2 years postoperatively. One (0.4%) patient underwent implant removal and conversion to fusion due to implant subsidence.

Conclusions: The overall complication and reoperation rates of TDR were relatively low: 1.5% and 1.1% in the perioperative period during hospitalization and 7.4% and 1.1% within the 2-year postoperative period after discharge, respectively. TDR achieved favorable outcomes with acceptable complication rates when performed under appropriate surgical indications.

Introduction: This study investigated brace treatment for patients with adolescent idiopathic scoliosis (AIS) to comprehensively evaluate the factors associated with curve progression, including the effects of in-brace correction rate (ICR) and objective brace compliance. Additionally, it aimed to establish a clinically useful optimal ICR threshold for effective curve progression control.

Methods: In this single-center retrospective analysis of prospectively collected data, 116 patients with AIS, with Cobb angles of 20°-40° and at least 1-year follow-up were included. Patients whose Cobb angles progressed by >5° were classified into the progressed group, whereas the others were categorized into the non-progressed group. Bracing time was objectively assessed using a thermometer.

Results: In this study, 19 (16.4%) patients were assigned to the progressed group. Open triradiate cartilage was significantly more frequent in the progressed group (22.2% vs. 2.6%, p= 0.011) whereas no significant differences were observed in demographics or pre-brace Cobb angles. The progressed group demonstrated a lower ICR (26.8% vs. 39.5%, p= 0.002) and shorter bracing time at 6 months (14.0 hours vs. 17.4 hours, p= 0.042). Multivariate logistic regression analysis revealed that Sanders grade (1-4), ICR, and bracing time were independently associated with Cobb angle progression (odds ratios: 7.01, 0.95, and 0.89, respectively; all p< 0.05). Based on receiver operating characteristic curve analysis, the ICR threshold of 38.3% was identified to achieve a clinically significant negative predictive value of 95%.

Conclusions:Under objective bracing time monitoring, skeletal maturity, ICR, and bracing time were crucial factors in preventing curve progression 1 year after brace initiation in patients with Cobb angles of 20°-40°. An ICR of 38.3% is recommended as the target when bracing adjustments are feasible.

Lumbar disc herniation (LDH) is one of the main causes of low back pain, and far lateral lumbar disc herniation is a specific type of LDH. Owing to the limitation of the bony structure and surrounding ligaments in the foraminal area, the closer the protrusion inside and outside the foramen is to the exiting nerve root ganglia, the more severe the compression. Therefore, the clinical symptoms of this type of LDH are more pronounced, and timely diagnosis and treatment are required. Some patients can experience pain relief through conservative treatment, whereas others require surgical intervention. Spine surgeons can choose different surgical options according to the patient's condition and their own surgical habits, such as traditional surgery, microendoscopic discectomy, percutaneous endoscopic lumbar discectomy, and unilateral biportal endoscopy. There are different characteristics between traditional surgery and minimally invasive surgery, and there are also different characteristics between different minimally invasive surgeries. This article reviews the anatomical structure, clinical manifestations, and various treatment approaches.

Objective To predict the onset of dysphagia in hospitalized patients with osteoporotic vertebral fractures (OVF) early after admission and to investigate cutoff values for risk factors.

Methods The subjects were 341 hospitalized patients with OVF. We excluded 30 cases as the required data could not be measured, and 25 cases with conditions that could contribute to dysphagia, such as neurological or respiratory comorbidities. Gender, age, number and level of OVF, collapse rate (CR) of OVF, thoracolumbar kyphosis angle (KA), bone mineral density (BMD), systemic skeletal muscle mass index (SMI), and body mass index (BMI) were examined by dividing the patients into those with dysphagia (the P group) and others (the N group).

Results There were 26 cases in the P group and 260 cases in the N group, with no significant difference in the male-female ratio, number, and level of OVF. The mean values of CR (%), KA in the P group/the N group were 40.0/36.1, 16.7/17.8, and the mean values of age, BMD (%), SMI (kg/m²), and BMI (kg/m²) in the P group/the N group were 86.4 /82.3, 64.5/71.6, 4.43/5.58, 20.0/22.1 in men, 85.7/83.4, 55.1/63.8, 4.43/4.99, 19.4/21.6 in women, with significant differences in SMI in men and women and BMD in women. Analysis of SMI and BMD in women using a multivariate logistic model with dysphagia as the dependent variable showed that low SMI was an independent risk factor. The cutoff value, sensitivity, specificity, and area under the receiver operating characteristic curve for SMI were calculated. For men, the values were 4.610 kg/m², 0.867, 0.750, and 0.829, respectively, and for women, 4.410 kg/m², 0.790, 0.571, and 0.687, respectively.

Conclusions A correlation was found between dysphagia and SMI in patients with OVF. For patients with SMI below the cutoff value, early swallowing evaluation and training intervention are considered important.

Background: Accurate pedicle screw placement is critical in spinal fusion surgery to prevent complications such as neurological and vascular injuries. While conventional intraoperative computed tomography (iCT) navigation systems enhance placement accuracy and reduce radiation exposure compared to fluoroscopic guidance, they can encounter line-of-sight issues that disrupt surgical workflows. The NextAR iCT navigation system aims to overcome these challenges by integrating an infrared camera directly onto surgical instruments, streamlining navigation and improving procedural efficiency.

Methods: This retrospective study evaluated the accuracy and safety of pedicle screw insertion using the NextAR navigation system in lumbar spinal fusion for degenerative diseases. We analyzed 307 screws using a CT-based grading system.

Results: Among the 307 screws inserted, only 8 (2.6%) exhibited minor deviations (grade 1 or 2), with no severe perforations (grade 3 or 4). There were no neurological or vascular complications related to screw placement. The NextAR system enabled precise pedicle screw insertion without the need for fluoroscopic guidance, eliminating radiation exposure for the surgical team.

Conclusions: The NextAR navigation system demonstrated high accuracy and safety in pedicle screw placement for lumbar degenerative diseases. By addressing line-of-sight issues inherent in traditional navigation systems and eliminating intraoperative radiation exposure, it offers significant procedural advantages. Further randomized controlled trials are needed to compare its effectiveness with other advanced navigation systems.

Introduction: This study aimed to compare the outcomes in patients who received non-steroidal anti-inflammatory drugs (NSAIDs) ≤90 days or 90 days-1 year after posterior cervical fusion (PCF) with those in patients who did not receive NSAIDs after surgery.

Methods: Using the MarketScan® Research Databases, we analyzed adults (18–90 years) who underwent PCF and adjusted for confounders with inverse probability of treatment weighting (IPTW) to compare outcomes in those receiving NSAIDs ≤90 days or 90 days-1 year after surgery and those not receiving NSAIDs within a year. In one analysis, we included single- and multi-level PCF, and in a sub-group analysis, we focused on single-level PCF. Outcomes included 30-day readmissions, pseudoarthrosis, hardware failure, and wound complications.

Results: After IPTW, NSAID use ≤90 days of single- and multi-level PCF was not associated with increased readmissions, pseudoarthrosis, or wound complications. However, NSAID use 90 days-1 year increased the odds of pseudoarthrosis and hardware failure (odds ratio 1.157, 95% confidence interval 1.075-1.245, p < 0.001). In single-level PCF, NSAIDs use ≤90 days or 90 days-1 year of surgery was not associated with increased odds of complications. No difference was observed in postoperative complications between patients who took COX-2 selective inhibitors and those who took non-selective NSAIDs.

Conclusions: NSAID use ≤90 days of surgery does not increase the risk of adverse outcomes for either single- or multi-level PCF, suggesting it may be a viable option for pain management. Postoperative NSAID use 90 days-1 year does not seem to increase complications in single-level PCF. However, caution is advised for multi-level fusions or cases with complex clinical factors, in which NSAID use from 90 days-1-year postoperatively may increase the risk of pseudoarthrosis and hardware failure.

Introduction: Surgical outcomes for adult patients with residual adolescent idiopathic scoliosis (AdIS) with a major thoracic curve are expected to be inferior to those of AIS but have not been well reported. This study aimed to evaluate surgical, radiographical, and clinical results in adult patients with AdIS and to characterize these patients by comparing their results with those of patients with adolescent idiopathic scoliosis (AIS).

Methods: Thirty-five patients with AdIS, who were diagnosed with AIS Lenke type 1 or 2 before the age of 19 years and underwent surgery after the age of 20 years, were included in the study. As a control group, 84 patients with AIS Lenke type 1 or 2 who underwent surgery before the age of 19 were included. Both groups were matched on the basis of the preoperative main thoracic (MT) and proximal thoracic (PT) Cobb angles, causing 30 patients to be selected in each group.

Results: The AdIS group exhibited a greater preoperative bending Cobb angle of the MT and PT curves (MT: 35.1° vs. 31.3°, PT: 17.8° vs. 13.8°) and a lower MT curve flexibility index than in the AIS group (36.6% vs. 42.2%). Postoperatively, the AdIS group had a higher number of fused intervertebral segments than did the AIS group (8.2 vs. 7.4), but the correction rate was comparable in the 2 groups. Moreover, the intraoperative time was longer and blood loss was larger in the AdIS group. In the Scoliosis Research Society (SRS) -22 score, self-image and mental health domains were significantly lower preoperatively in the AdIS group. Postoperative improvement of self-image domain was significantly greater in the AdIS group (Δ self-image: 1.6 vs. 0.9), and postoperative satisfaction was similar in the 2 groups.

Conclusions: Surgical invasiveness was increased in AdIS, and preoperative SRS-22 scores were lower in self-image and mental health domains than in AIS. However, postoperative SRS-22 scores were comparable, and postoperative self-image improvement was significantly greater in AdIS than in AIS.

Introduction: Proximal junctional kyphosis (PJK) in patients undergoing instrumented deformity correction surgery for adult spinal deformity (ASD) is found to be multifactorial. This review aims to provide comprehensive information on which factors affect PJK in ASD correction surgery including prevention strategies.

Materials and Methods: A literature review was conducted through a web search on PubMed with the following combination keywords: "proximal junctional kyphosis," "adult spinal deformity," and "risk factor" between January 2001 and June 2024. Primary outcomes of interest were divided into two groups: non-radiological parameters including patient characteristics and surgical techniques, and radiological parameters.

Results: The non-radiological parameters associated with PJK included age, body mass index, comorbidities, low bone quality, muscle degeneration, combined anterior–posterior surgical approach, rigid proximal instrumentation, upper instrumented vertebrae (UIV) selection in the junctional zone, long-segment fusion, and overcorrection. Moreover, lumbar lordosis, spinopelvic parameter, thoracic tilt, upper instrumented vertebra–femoral angle, fused spinopelvic angle, and UIV inclination were found to be the radiological parameters that influence the incidence of PJK in patient with ASD correction surgery.

Conclusion: Understanding the multifactorial aspects of PJK could aid in the preoperative planning and assessment for patients with ASD. Furthermore, the proposed correction should be based on an individualized approach.

Background: Cortical bone trajectory screw (CBTS) is reported to offer increased cortical bone purchase and improved outcomes as compared to the traditional pedicle screw (PS), particularly in osteoporotic patients.The systematic review aims to compare randomized controlled trials comparing CBTS with PS in single-level lumbar spine fusion surgery.

Methods: A systematic search was conducted on PubMed (MEDLINE), Scopus, Embase, Web of Science, and Cochrane. Moreover, ClinicalTrials.gov, International Clinical Trials Registry Platform (ICTRP), and China National Knowledge Infrastructure (CNKI) were also searched. Outcome measures included fusion rates, complication rates, perioperative parameters, pain scores, and functionality. (PROSPERO: CRD42024523809).

Results: Four manuscripts, reporting on three randomized controlled trials (RCTs) and 416 patients, were included in this review. The follow-up ranged from 24 to 26 months postoperatively. All patients underwent single-level fusion only. There was no significant difference in the fusion rates between CBTS and PS at one-year (risk ratio [RR] 1.05 [0.97, 1.13], p = 0.24) or two-year (RR 1.02 [0.96, 1.08], p = 0.47) follow-ups. The CBTS group had a lower risk of intraoperative complications (RR 0.44 [0.32, 0.60], p < 0.001) but an equal risk of postoperative complications (RR 0.71 [0.42, 1.22], p = 0.22). There was no difference in pain, functionality, disability, and quality-of-life scores. CBTS group had better outcomes in incision length (mean difference [MD] -25.44 [-40.76, -10.12], p = 0.001), operative time (MD -20.71 [-32.91, -8.51], p = 0.009), and blood loss (MD -60.23 [-106.74, -13.72], p = 0.01), while there was no difference in length of stay (MD -0.49 [-1.01, 0.04], p = 0.07).

Conclusions: Although slightly favoring CBTS, RCTs were limited in number and had a serious risk of bias. Future RCTs should use superiority trial designs, have minimal bias, and include implant details, incidence of adjacent segment disease, and quality-of-life metrics.

Background: Degenerative scoliosis is a progressive side-to-side deformity of the spine that is common in mature individuals, characterized by a Cobb angle of >10°. Current treatment options vary and can be categorized as conservative or non-conservative (surgery), with the primary goal of pain reduction. However, there is conflicting evidence regarding which treatment option is most effective. The aim of this study was to determine the effectiveness of braces in this group of subjects.

Methods: A systematic search was conducted in databases including PubMed, Web of Science, Scopus, and Embase for the period between 1950 and 2024. Keywords used were: (degenerative scoliosis OR adult scoliosis) AND (conservative treatment OR brace OR orthosis). The quality of the selected studies was evaluated using the Downs and Black tool.

Results: Of 500 papers identified in the search, a total of 11 studies were chosen for final analysis. Most of the selected studies focused on the effects of various types of braces on pain intensity, quality of life, and functional performance in subjects with degenerative scoliosis.

Conclusions: Based on the available literature and the lack of strong studies on the effectiveness of braces, it cannot be definitively concluded that the use of braces reduces the severity of scoliosis curves in adults with degenerative scoliosis. However, braces may have an impact on quality of life and pain severity in this group of subjects.

Introduction

The pathogenesis of dropped head syndrome (DHS) involves factors like fat infiltration of the cervical extensor muscle, cervical degeneration, and sarcopenia, which are typically assessed using conventional imaging. Previous studies have demonstrated cervical and thoracic anterior tilt deterioration during gait in patients with DHS. However, the relationship between dynamic spinal balance and conventional imaging findings has not been investigated. The purpose of this study was to investigate the walking posture of patients with DHS using 3D gait motion analysis and to analyze the relationship between dynamic posture and conventional imaging factors, leading to the investigation of the pathophysiology of cervical imbalance during gait in patients with DHS.

Methods

Twenty-two patients with DHS were included. Global and cervical static alignments were assessed using whole spine radiography. 3D gait motion analysis was performed, and dynamic kinematic variables were segmented into the cervical and thoracic regions. The paraspinal muscle activity was assessed using wireless surface electromyography. The cervical deep extensor muscle (C-DEM) condition was assessed using magnetic resonance imaging. Correlations of changes in dynamic kinematic variables with paraspinal muscle activity and C-DEM condition were determined.

Results

A significant change in the anterior cervical and thoracic spine tilt was observed during gait. These changes were inversely correlated with thoracic paraspinal muscle activity. The change in the cervical anterior tilt was significantly correlated with the fat-free C-DEM at C3/C4 and C4/C5 and the fat infiltration rate of the C-DEM at C5/C6 and C7/T1.

Conclusion

The thoracic paraspinal muscle activity failed to respond to the deterioration of the thoracic anterior tilt, indicating a notable contribution to postural endurance during gait and to DHS pathogenesis. Evaluating the condition of the C-DEM could be an alternative for evaluating dynamic postural endurance and is clinically important when considering patient complaints regarding difficulties in daily activities.

Introduction: Cervical compressive myelopathy is a leading cause of spinal cord dysfunction in middle-aged and older adults. Although the pathological classification of cervical myelopathy is well established, the quantitative analysis of its imaging features remains underexplored. This study quantitatively evaluated the imaging characteristics of unilateral motor deficit cervical compressive myelopathy.

Methods: This retrospective observational study included patients who underwent surgery for cervical compressive myelopathy between 2009 and 2023. Pre-operative cervical magnetic resonance imaging (MRI) and postmyelographic computed tomography (CTM) axial images were assessed for spinal cord rotation, deformity, available space, and signal changes. Patients were classified into unilateral motor deficit (Group U) and symmetric transverse (Group ST) types, and were analyzed for specific imaging parameters.

Results: The final analysis included 119 of the 812 identified patients. Group U patients were younger (59.1 ± 13.8 years) and had higher Japanese Orthopaedic Association scores (10.6 ± 2.7) compared with Group ST patients (71.1 ± 11.0 years, 8.4 ± 2.3). Group U showed significant morphological differences, including a reduced anterior-subarachnoid space and increased spinal cord rotation on the affected side. Group U exhibited significant differences in the median fissure rotation angle (7.4° ± 6.7°) and anterior-aspect rotation angle ratio (1.26 ± 0.31) compared with Group ST (4.14° ± 3.87°, 1.10 ± 0.14). Receiver operating characteristic curve analysis identified specific cutoff values for distinguishing Group U (2.80° for median fissure rotation angle and 1.116 for anterior-aspect rotation angle ratio). The MRI-based detection sensitivity was lower in Group U (27.6%) compared with in Group ST (68.9%).

Conclusions: Unilateral motor deficits are associated with distinctive spinal cord rotational deformities, including a greater median fissure rotation angle and anterior-aspect rotation angle ratio. CTM is better than MRI for detecting unilateral motor deficits. Future research to improve treatment outcomes should focus on spinal cord circulation assessment using advanced imaging techniques.

Introduction Impaired standing alignment and postural instability diminish health-related quality of life (HRQOL). Reduced trunk muscle mass is correlated with worsened spinal alignment and HRQOL in patients with spinal disease. However, the interplay among standing balance, whole-body alignment, muscle mass, and HRQOL remains unclear. This study aimed to elucidate this relationship.

Methods This study evaluated the influence of whole-body alignment, standing balance, skeletal muscle mass (SMM), aging, and sex on HRQOL in healthy volunteers (HV; men/women: 37/63, median age: 45), patients with lumbar degeneration (LD; men/women: 100/100, median age: 65), and patients with spinal deformity (SD; men/women: 16/84, median age: 71). HRQOL was assessed using the Scoliosis Research Society-22 (SRS-22r). Whole-body alignment and standing balance were measured using EOS Imaging combined with simultaneous force plate measurements. SMM was measured using a medical body composition analyzer. Based on univariate analysis and multicollinearity, 10 selected parameters were used in multivariate logistic regression analysis to identify factors affecting SRS-22r.

Results The SRS-22r score was significantly higher in the HV group than in the LD and SD groups; however, there were no significant differences between men and women. The whole-body alignment and standing balance were better in the HV group, followed by the LD and SD groups. The total-body SMM (SMM.total) of men was significantly lower in the LD and SD groups than in the HV group. In females, the SMM.total was significantly lower in the SD group than in the HV and LD groups. However, trunk SMM did not significantly differ among the three groups. Based on the multivariate analyses, diagnosis, body mass index (BMI), SMM.total, lumbar lordosis (LL), and T1 pelvic angle (TPA) were correlated with the SRS-22r score.

Conclusion HRQOL was negatively affected by spinal disease, as well as by higher BMI, lower SMM.total, and sagittal malalignment (smaller LL and greater TPA).

Introduction: Some cases of postoperative correction loss have been observed in the reduction of vertebral slippage using a percutaneous pedicle screw system for lumbar degenerative spondylolisthesis. We aimed to identify the risk factors for correction loss after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and to determine the effect of postoperative correction loss on postoperative clinical outcomes.

Methods: In this retrospective study, a total of 111 patients (mean age 69.5 years, 37 men and 74 women) who underwent single-level MIS-TLIF with slippage reduction for lumbar degenerative spondylolisthesis and were followed up for >1 year were included in the study. The correction loss group (group L) included those with a correction loss of ≥3 mm between immediately after surgery and 1 year after surgery, and the correction maintenance group (group M) included those with a correction loss <3 mm. Demographic data, preoperative and postoperative radiographic measurements, and clinical outcomes were collected, and the risk factors in group L and clinical outcomes in the two groups were analyzed statistically.

Results: Groups L and M comprised 19 and 92 cases, respectively. High pelvic incidence-lumbar lordosis (odds ratio [OR]: 1.16, 95% confidence interval [CI]: 1.07-1.25, p < 0.001), high slip vertebra slope (OR: 1.22, 95% CI: 1.07-1.39, p < 0.001), and ≥10° segmental angulation (OR: 15.00, 95% CI: 3.04-73.95, p = 0.0022) were risk factors for correction loss; however, low bone density was not. The Oswestry Disability Index and Visual Analog Scale scores for low back pain, leg pain, and leg numbness were not significantly different between both groups; however, the bone union rate at 6 months postoperatively was significantly lower in group L (p = 0.0020).

Conclusions: Postoperative correction loss was influenced by preoperative sagittal alignment and instability rather than bone density. Patients with correction loss tend to have prolonged bone union and should be closely monitored.

The study investigated the complications of adult spinal deformity (ASD) surgery in Japan in 2022 using the Japanese Orthopedic Association National Registry/Japanese Society for Spine Surgery and Related Research Database (JOANR/JSSR-DB).

Methods

Among the 158,407 patients registered in JOANR/JSSR-DB, 4,822 patients aged ≥19 years (1,115 males [23.1%], 3,707 females [76.9%]) were included in this study. Diagnoses were scoliosis in 1,961 patients (40.7%), kyphosis in 1,613 patients (33.4%), and kyphoscoliosis in 1,248 patients (25.9%). Intra-operative and postoperative/systemic complications (within 30 days) were investigated.

Results

The age distribution was 468 (9.7%) aged 19–39, 855 (17.7%) aged 40–64, 1,779 (36.9%) aged 65–74, and 1,720 (35.7%) individuals aged ≥75 years, with 72.6% of the total population aged ≥65 years. The total complication rate was 11.8% (567 patients), with 6.2% in patients aged 19–39 years, 12.6% in patients aged 40–64 years, 11.6% in patients aged 65–74 years, and 13.0% in patients aged ≥75 years, whose rate was significantly higher (p < 0.001). Intra-operative complications occurred in 215 patients (4.5%). Dural tear in 110 patients (2.3%), massive bleeding (>2,000 ml) in 54 (1.1%), implant-related complications in 14 (0.3%), and intra-operative nerve injury in 10 patients (0.2%). Postoperative complications occurred in 266 patients (5.5%). Lower extremity paralysis in 99 patients (2.0%), surgical site infection in 55 (1.1%), vertebral body or endplate injury in 25 (0.5%), epidural hematoma in 18 (0.4%), and weakness of the iliopsoas muscle due to lateral lumbar interbody fusion in 21 patients (0.4%). Systemic complications occurred in 162 patients (3.4%) with urinary tract infection in 29 (0.6%) and postoperative delirium in 26 (0.5%).

Conclusion

While the 11.8% total complication rate was lower than previous reports, rates were higher in patients aged ≥75, indicating the need for careful perioperative management in elderly patients.

Introduction: Lumbar spondylolysis (LS) is a stress fracture of the pars interarticularis that can occur in adolescents. Both early- and progressive-stage LS can be successfully treated with conservative therapy consisting of activity modification and external bracing; however, conservative therapy is not suitable for athletes who hope for an early return to sports. We introduce a novel, minimally invasive surgical technique for the treatment of LS that enables an early return to sports and describe surgical results, including bone union rates, time of both bone unions, and return to sports.

Technical Note: To facilitate an early return to sports in adolescent athletes with early-to-progressive-stage LS, we developed a percutaneous spondylolysis repair technique using cannulated compression headless screws with a cortical bone trajectory. Fourteen adolescent athletes underwent this technique; as a result, all athletes achieved bone union and returned to sports within 3 months.

Conclusions: This minimally invasive surgical technique for LS can achieve early bone union in adolescent athletes, thereby facilitating an early return to sports.

Introduction: Japan is experiencing a significant demographic shift characterized by a declining birthrate and an aging population. A previous report indicated a discrepancy between the trends in the number of spinal surgeries performed for minors and the overall population dynamics. Japan has the National Database of Health Insurance Claims and Specific Health Checkups (NDB), which contains 99.9% of public health insurance claims from hospitals and 97.9% from clinics. This study aimed to investigate the annual number of scoliosis surgeries performed on patients aged 19 years in Japan, evaluate trends in relation to the overall population dynamics, and examine potential factors contributing to the observed changes.

Methods: This retrospective study utilized NDB and census data. Scoliosis surgeries were identified using K-codes specific to the procedure. Population data were estimated using census and national birth records released by the Japan Cabinet Office. The number of surgeries per 100,000 minors was calculated, and trends were analyzed from 2014 to 2021.

Results: The number of scoliosis surgeries for patients under 19 years old increased from 1,282 in 2014 to 1,850 in 2021, despite a decrease in the number of patients under 19 years old. The rate of scoliosis surgeries per 100,000 minors increased from 5.6 in 2014 to 9.1 in 2021, whereas other spinal fusion procedures for minors did not show significant changes during the same period.

Conclusions: Despite a decline in the underage population, the number of scoliosis surgeries among minors has paradoxically increased in Japan. Improvements in screening tools and the April 2016 change in the law mandating a full motor examination, including scoliosis testing, may have affected this trend. Further follow-up studies are required.

Introduction

Postoperative infection remains a significant concern and technical challenge for spine surgeons. Preoperative albumin level may predict risk of infection, but no definitive consensus regarding the optimal preoperative albumin level in anterior cervical discectomy and fusion (ACDF) has been reached. Therefore, this study aimed (1) to determine the impact of preoperative albumin on complications following ACDF and (2) to identify optimal albumin threshold that minimizes the likelihood of infection following ACDF.

Methods

A retrospective cohort analysis was performed using a national database. Patients with a preoperative measurement of albumin prior to ACDF were included, whereas patients undergoing multilevel ACDF were excluded. Stratum-specific likelihood ratio (SSLR) analysis was conducted to determine data-driven albumin strata that minimized the likelihood of infectious complications within 30 days of ACDF.

Results

A total of 30,896 ACDF patients were included in this study. Stratum-specific likelihood ratio analysis identified two albumin strata: 1–3 and 3+ g/dL prior to surgery. Relative to the 3+ g/dL cohort, the 1–3 g/dL cohort was more likely to experience 30-day infectious complications such as deep surgical site infection (SSI) (OR: 8.02, P < 0.001) and SSI domain (OR: 4.85, P < 0.001).

Conclusion

This study demonstrates a significant association between preoperative albumin level and infectious complications following ACDF. These results emphasize the importance of integrating nutritional management strategies into the broader context of surgical decision-making, thus contributing to enhanced patient outcomes and quality of care in spine surgery.

Introduction: Thoracic ossification of the ligamentum flavum (T-OLF), which leads to neurological impairment, is a rare pathologic entity. Open posterior laminectomy is the gold standard treatment for T-OLF. However, the high rates of postoperative complications and perioperative morbidity have raised many concerns among surgeons. This study presented a series of patients with symptomatic single-level T-OLF who underwent posterior decompression using biportal endoscopic spinal surgery (BESS). The objective of this study was to demonstrate our procedure using BESS for T-OLF resection and to evaluate its safety and efficacy.

Methods: We retrospectively reviewed patients who previously underwent thoracic posterior decompression with BESS between February 2021 and March 2023. Neurological status was assessed using the revised Japanese Orthopedic Association (JOA) score for thoracic myelopathy before surgery and at the final follow-up, along with the recovery rate (RR) at the final follow-up. The radiological outcome was evaluated by measuring the cross-sectional area (CSA) of the spinal canal from the T2 axial images at the most stenotic level, before and after surgery.

Results: Twenty patients (8 male and 12 female; aged between 38 and 79 years) were enrolled in this study. The mean operation time was 89.7 ± 21.8 min. The average JOA score was 5.6 ± 1.1 before surgery and 9.1 ± 1.0 at the final follow-up. The average RR at the final follow-up was 65.6%. Outcomes were classified as excellent in six patients (30.0%), good in nine patients (45.0%), and moderate in five patients (25.0%), with no cases categorized as fair or worsened (0%). The mean preoperative and postoperative CSA were 0.92 ± 0.14 cm² and 1.38 ± 0.22 cm², respectively.

Conclusions: BESS is a safe, effective, and minimally invasive alternative to conventional open surgery for single-level T-OLF.

Introduction: Despite an increase in the demand for surgical treatment of elderly patients with degenerative spinal disorders, little is known about mortality following spinal surgery in this population. This study aims to identify the incidence and causes of in-hospital mortality in elderly patients after elective spine surgery.

Methods: We extracted the data of patients aged ≥65 years who underwent elective spine surgery between December 12, 2016, and May 31, 2022, from our prospective multicenter cohort. The primary outcome was the in-hospital mortality rate. Univariate analysis was conducted to identify potential risk factors for postoperative mortality. The detailed clinical course of patients who died was retrospectively investigated using medical records.

Results: A total of 10,976 eligible patients (5,976 males and 5,000 females), with a mean age of 75.5 years, were identified. There were eight in-hospital deaths (0.07%). Univariate analyses showed that the eight patients were significantly older (82.1 years vs. 75.5 years, P = 0.008), were more frequently hemodialysis-dependent (50.0% vs. 2.9%, P < 0.001), and had a higher proportion of cases with cervical surgery (62.5% vs. 17.0%, P < 0.001) and preoperative American Society of Anesthesiologists Physical Status ≥ 3 (87.5% vs. 14.6%, P < 0.001). Death occurred at a median of 24.5 days postoperatively. The causes of in-hospital death were as follows: gastrointestinal diseases in five cases (ischemic colitis in three cases, panperitonitis in one, and intestinal perforation in one), sepsis due to unknown causes in two, and lethal arrhythmia in one. The initial symptoms preceding the lethal clinical course were mainly common gastrointestinal symptoms, such as abdominal pain, anorexia, diarrhea, and vomiting.

Conclusions: The main cause of in-hospital mortality was gastrointestinal disease. Surgeons should be aware that common gastrointestinal symptoms can be the initial symptoms of a subsequent lethal clinical course in elderly patients.

Introduction: Acute celiac artery compression syndrome occurs after corrective surgery for adult spinal deformity. It occurs due to ischemic abdominal organ necrosis, caused by compression of the celiac artery (CA) and superior mesenteric artery by the median arcuate ligament. There are no studies measuring the extent of CA or superior mesenteric artery stenosis. Therefore, this study aimed to investigate stenotic changes in the CA after adult spinal deformity surgery.

Methods: We obtained contrast-enhanced computed tomography scans for 21 pre-and postoperative patients with adult spinal deformity. Three-dimensional reconstruction computed tomography measured the degree of stenosis in the CA trunks. Stenosis was considered worse if it progressed from being less than 35% before surgery to over 50% afterward. This study investigated the relationship between worsening CA stenosis and the median arcuate ligament crossing the proximal portion of the celiac axis (median arcuate ligament overlap) or the distance between the median arcuate ligament and the anterior edge of the vertebra (DMV). Change in spinal parameters was defined as differences between pre- and postoperative values.

Results: The average stenosis degree in the CA was 9.4% ± 11.4% pre-operatively, which increased to 25.1% ± 21.8% post-operatively (P = 0.002). In contrast, the stenosis degree in the superior mesenteric artery was 5.6% ± 7.1% before and 7.9% ± 10.2% after surgery (P = 0.177). CA stenosis worsened in four patients (19.0%), which was significantly associated with preoperative median arcuate ligament overlap (P = 0.012) and ΔDMV (P < 0.001).

Conclusions: Nineteen percent of patients undergoing adult spinal deformity correction surgery experienced worsened CA stenosis. Risk factors were preoperative median arcuate ligament overlap and DMV shortening during adult spinal deformity correction surgery. Moreover, patients with preoperative CA stenosis and median arcuate ligament overlap were at risk for acute celiac artery compression syndrome following adult spinal deformity surgery.

Introduction: Cervical pedicle screw (CPS) placement is crucial for posterior cervical fusion surgery due to its strong fixation ability. However, CPS insertion is associated with risks, including screw perforation, which can lead to complications such as vertebral artery injury and neurological deficits. Although previous studies have explored some morphological factors affecting CPS placement, comprehensive data on specific parameters contributing to perforation remains limited. This study aimed to investigate cervical vertebrae features associated with CPS perforation and established threshold values for improved preoperative planning.

Methods: A retrospective analysis of 36 patients who underwent posterior cervical fusion surgery with CPS placement was conducted using preoperative computed tomography (CT) -based navigation. Cases with CPS insertion at C1 or C2 were excluded.. The key morphological parameters—optimal screw trajectory angle, pedicle diameter, and distance from the entry point to the pedicle isthmus (DEP) —were measured on preoperative CT images. CPS placement accuracy was assessed postoperatively using Neo' s classification. The receiver operating characteristic (ROC) curve analysis determined the cutoff values for predicting CPS perforation.

Results: Among the 102 CPSs placed from C3 to C7, the overall perforation rate was 25.5%. C3 had the highest perforation rate (45.5%), whereas C7 had the lowest (3.1%). The vertebrae with CPS perforation exhibited a significantly larger optimal screw trajectory angle (45.5° vs. 38.0°, p < 0.001), smaller pedicle diameter (4.2 mm vs. 5.2 mm, p < 0.001), and longer DEP (13.2 mm vs. 11.9 mm, p = 0.002). The ROC analysis identified the following cutoff values: 44.0° for the optimal angle, 4.35 mm for the pedicle diameter, and 12.7 mm for the DEP. These morphological parameters strongly predicted the risk of CPS perforation.

Conclusions: Establishing key morphological thresholds enhances preoperative planning for CPS placement, improves accuracy and patient safety, and minimizes complications.

Introduction: To compare the clinical outcomes between a full-endoscopic transforaminal approach lumbar interbody fusion (TF-LIF) using the percutaneous endoscopic transforaminal lumbar interbody fusion (PETLIF) system and a minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF).

Methods: A total of 102 patients (80 females, 22 males; mean age: 70.0 years) with degenerative lumbar spine disorders who underwent PETLIF and were followed up for 2 years were assigned to the PETLIF group. Based on age, sex, and operated lumbar levels in the PETLIF group, 100 patients (71 women and 29 men; mean age: 68.9 years) who underwent MIS-TLIF were randomly selected and included in the MIS-TLIF group. This retrospective investigation included surgical data, radiographic assessment, and clinical outcomes.

Results: The fusion rate was 95.1% and 96.0% in the PETLIF and MIS-TLIF groups, respectively (P = 0.38). The decrease in hemoglobin levels from before surgery to 1 day after surgery was significantly lower in the PETLIF group than in the MIS-TLIF group (P < 0.01). Five patients had detectable transient neurologic disorders after PETLIF that were resolved within 3 months. The increase in the local lordosis angle from before surgery to the final follow-up was significantly higher in the MIS-TLIF group than in the PETLIF group (P < 0.01). Clinical scores were comparable between the two groups.

Conclusions: Compared with MIS-TLIF, PETLIF showed excellent bone fusion rate and clinical outcomes. It was minimally invasive, resulting in less blood loss. However, exiting nerve root injury was a PETLIF-specific complication, and proper preventive management, including techniques to enlarge the Kambin's triangle, is required.

Introduction: To estimate natural standing sagittal alignment in patients with adult spinal deformity (ASD), we previously reported the normative values of anatomical pelvic parameters in a healthy population, based on the anterior pelvic plane (APP), and observed the relationships between anatomical and positional pelvic parameters in the standing position. As the second step, we aim to investigate the relationships between anatomical pelvic parameters and standing spinal sagittal alignment in a healthy population.

Methods: We analyzed biplanar, slot-scanning, full-body stereo radiography of 140 healthy Japanese volunteers (mean age, 39.5 years; 59.3% women). The APP was defined by bilateral anterior superior iliac spines and anterior surface of the pubis symphysis. Anatomical sacral slope (aSS) and anatomical pelvic tilt (aPT) were calculated as angles of the SS and PT regarding the APP.

Results: The APP was tilted anteriorly in the sagittal plane by an average of 0.7°. Anatomical pelvic parameters significantly correlated with standing sagittal parameters, except for cervical lordosis and T4–12 thoracic kyphosis (TK) (p<0.05). L4-S1 lumbar lordosis (LL) significantly correlated with aPT and aSS, but not with pelvic incidence (PI). In addition, T1–12 TK significantly correlated with aSS. Multiple linear regression analysis for lumbar alignment produced the following equations: L1–S1 LL (°) = 0.588 × aSS + 30.522, L4–S1 LL (°) = 0.165 × aSS − 0.248 × aPT + 32.825, lordosis distribution index (%) = −0.662 × PI + 102.8.

Conclusions: Novel relationships in a healthy population were identified between the anatomical characteristics of the pelvis and standing sagittal parameters not represented by PI. This novel measurement concept based on the APP may estimate natural standing sagittal alignments and proportions using anatomical pelvic parameters in ASD.

Introduction: Chemonucleolysis with condoliase (chondroitin sulfate ABC endolyase) has been widely employed to treat patients with lumbar disc herniation (LDH) in Japan. Although it is an effective and relatively safe treatment for radicular neuropathy in patients with LDH, there have been no reports that investigate how severe low back pain (LBP) changes after condoliase injection. In this multicenter study, the effectiveness of condoliase injection for reducing severe LBP in patients with LDH was evaluated.

Methods: This retrospective study involved patients treated with intradiscal condoliase injection for LDH at nine participating centers. Patients were diagnosed with subligamentous-type herniation based on pretreatment MRI. Patients with severe LBP (defined as a preinjection numeric rating scale [NRS] for LBP greater than or equal to that for leg pain) were categorized into the LBP group. Demographic data, adverse events, treatment costs, and the NRS for LBP and lower extremity pain were analyzed. A 50% response was defined as ≥50% improvement in the NRS at 1 year postinjection. On the basis of the Pfirman classification, the LBP group was divided into less-degenerative (Grades II and III) and degenerative (Grades IV and V) subgroups.

Results: Seventy-nine patients were classified into the LBP group. Of these patients, 61 (77.2%) showed a >50% reduction in LBP, and another 61 (77.2%) demonstrated a >50% reduction in lower extremity pain. Improvement of lower limb pain was considerably better in the less-degenerative group than in the degenerative group, whereas that of low back pain was similar between the two subgroups. Medical costs, which include remuneration for injection, drug fees, inpatient costs, and other expenses, were similar between the LBP group and all cases.

Conclusions: This retrospective multicenter study revealed that patients with LDH with severe LBP frequently experienced improvement in radicular pain and LBP, which is similar to LDH cases without severe LBP.

Introduction: Surgical interventions for cervical spine and spinal cord diseases may lead to life-threatening postoperative airway obstruction, requiring urgent airway management. This study aimed to assess the feasibility and effectiveness of our respiratory management protocol for patients undergoing anterior cervical approaches, posterior occipitocervical fusion, and intramedullary tumor resection.

Methods: This single-center retrospective study consisted of 497 patients who underwent cervical surgeries, including anterior fusion, posterior occipitocervical fusion, combined anterior and posterior fusions, and intramedullary tumor resection between January 2006 and June 2022. Our institution implemented a specific postoperative airway management protocol from September 2014 onward. The protocol involved continued intubation for at least the first postoperative night, followed by a spontaneous breathing trial with a cuff leak test and extubation one or more days after surgery. We compared the outcomes between the pre-protocol period (non-protocol group, n = 234) and the protocol period (protocol group, n = 263).

Results: There were no significant between-group differences regarding demographic, clinical, or surgical details. In the non-protocol group, four subjects required reintubation because of postoperative airway complications (anterior fusion: 1 patient, posterior occipitocervical fusion: 1 patient, and intramedullary tumor resection: 2 patients). After the airway protocol implementation, the reintubation rate dropped to zero (P = 0.048).

Conclusions: Our airway management protocol substantially reduced the need for reintubation. These findings emphasize the importance of postoperative respiratory management after cervical spine surgeries and underscore the need for appropriate measures to prevent complications.

Background: Spinal fusion is a common form of orthopedic surgery, the most common of which involves pedicle screw placement (PSP). Despite well-documented benefits, pedicle screws are associated with several intraoperative complications. This area of surgery has subsequently been recipient to many surgical developments. Currently, augmented reality surgical navigation (ARSN) is at the forefront of surgical interest. This systematic review evaluates whether, when compared to freehand, fluoroscopic, and intraoperative image-guided navigation, ARSN results in superior screw accuracy and operative outcomes for patients undergoing PSP surgery.

Methods: Data collection was performed on PubMed, Ovid MEDLINE, the Cochrane Library, Embase, and the Web of Science between January 7, 2023, and January 8, 2024. PRISMA guidelines were followed and the level of evidence was graded per the Centre for Evidence-Based Medicine' s recommendations. Risk of bias was assessed per the ROBINS-I tool and the Cochrane guide for assessing study quality. A modified version of the Newcastle–Ottawa Scale was used to determine the certainty of the body of evidence.

Results: A total of 521 papers were obtained from all bibliographical databases, 31 of which were included in the final review. ARSN resulted in a significantly greater number of screws placed as Gertzbein and Robbins grade 1 or 2 (93.33% vs 85.86%, p < 0.000), significantly reduced intraoperative blood loss (470.32 vs 802.44 ml, p = 0.050), comparative operative duration (281.6 vs 255.5 min, p = 0.819), comparative time to place a screw (2.71 vs 3.1 min, p = 0.703), and a nonsignificant reduction in hospital stay (5.4 vs 7.5 days, p = 0.097). Maximum follow-up was more than 14 days.

Conclusion: ARSN results in a significantly greater number of screws placed at Gertzbein–Robertson grade 1 or 2 than non-ARSN surgery. Therefore, ARSN can be considered as a safe and efficacious technical innovation within PSP surgery.

Introduction: Cage subsidence (CS) after posterior or transforaminal lumbar interbody fusion (PLIF or TLIF) is challenging; however, its impact on health-related quality of life (HRQOL) remains unclear. This study aimed to explore the impact of CS occurrence on HRQOL and identify the risk factors in patients following PLIF or TLIF.

Methods: A total of 138 patients (mean age, 67 years; follow-up period, 12 months) who underwent single-level PLIF or TLIF were retrospectively analyzed. CS was defined as >1 mm sinking of the intervertebral cage evaluated via computed tomography. The patients were divided into the CS and nonsubsidence (NS) groups. HRQOL was assessed using the Oswestry Disability Index (ODI) scores.

Results: Among the 138 patients, 30 (22%) developed CS following PLIF or TLIF. All cases with TLIF surgery (n = 25) involved the use of one cage. A significant difference was observed in the use of two cages between the CS and NS groups (20.0% vs. 48.1%; P = 0.006). The CS group had lower occupancy rate of autograft soon after the operation than the NS groups (P = 0.002), and the occupancy rate of autograft tended to decrease in the CS group compared with the NS group over time. The ODI scores improved in both groups postoperatively; however, the NS group exhibited greater improvements in ODI scores from 4 months postoperatively. The CS group had a significantly lower proportion of patients with intervertebral osseous union at 6 and 12 months postoperatively compared with the NS group (P = 0.003 and P < 0.001, respectively).

Conclusions: The use of two intervertebral cages may enhance initial stability and reduce CS risk after PLIF. Initial intervertebral stability was crucial to preventing CS occurrence, as evidenced by the high occupancy rates of autograft in patients without CS. Surgical factors, including surgical strategy and intraoperative techniques, should be considered to prevent CS occurrence and to improve surgical outcomes and patient satisfaction.

Purpose Spinal alignment in women with osteoporosis tends to deteriorate with advancing age, and this misalignment may serve as an indicator of future fall-related fractures. Vertebral fractures, which commonly occur in patients with osteoporosis, have distinct characteristics compared with other fall-related fractures and should therefore be separately evaluated. This study aimed to investigate the association between future fall-related fractures and sagittal spinal alignment, excluding vertebral fractures.

Methods A total of 333 women with osteoporosis were recruited and followed up between November 2013 and July 2024. At baseline, information on medication status and bone mineral density in the lumbar spine and femoral neck was obtained from the patients' medical record. Furthermore, the locomotive syndrome (LOCOMO) stage was assessed via risk tests, and sagittal alignment parameters, including sagittal vertical axis (SVA), thoracic kyphosis (TK), pelvic incidence (PI), and lumbar lordosis (LL), were evaluated. In addition, Cox proportional hazards regression analysis was conducted to determine the risk of fall-related fractures based on all variables.

Results The mean follow-up period was 5.4 years. The final sample for assessing fall-related fracture incidence consisted of 214 participants. Fall-related fractures occurred in 31 of the 333 participants (9.3%). Cox proportional hazards regression analysis, adjusted for all variables, revealed that SVA (hazard ratio [HR] = 1.014, 95% confidence interval [CI] 1.006–1.023), LL (HR = 1.048, 95% CI 1.017–1.079), LOCOMO stage (HR = 1.806, 95% CI 1.113–2.879), and presence of parathyroid hormone (HR = 0.165, 95% CI 0.031–0.891) are independent risk factors for future fall-related fractures.

Conclusions Awareness of fall-related fracture risks can be increased by monitoring the SVA, LL, and LOCOMO stage as well as administering parathyroid hormone medications. While the deterioration of sagittal spinal alignment is a well-known factor in vertebral fractures, this study suggests that future fall-related fractures, excluding vertebral fractures, are influenced by sagittal spinal alignment.

Introduction: Proper cervical sagittal alignment is essential for maintaining overall spinal stability and function. A crucial measure of this alignment is the T1 slope, which is an important indicator. However, lateral cervical spine radiographs often fail to clearly show the T1 slope owing to several factors, such as shoulder anatomy or variations in body shape. In this study, we aimed to evaluate the differences in cervical alignment between individuals with visible and invisible T1 slopes.

Methods: This study was a retrospective cohort analysis involving 60 patients diagnosed with cervical spine conditions and evaluated via radiographic imaging. The patients were categorized into two groups based on whether the T1 slope was clearly visible or not. Key radiographic measurements, such as the C2–C7 sagittal vertical axis (SVA) and C2–C7 Cobb angles in the neutral, flexion, and extension postures, were recorded and statistically analyzed.

Results: Significant differences were observed in the C2–C7 SVA between the groups, particularly among men. Men in the invisible T1 slope group had an average SVA of 28.9 mm, whereas those in the visible group had a mean SVA of 16.0 mm (P < 0.05). Although no notable differences were observed in the Cobb angles for the neutral and flexion positions, a substantial reduction in the extension Cobb angle was noted in the invisible than in the visible group (24.4° vs. 37.6°, P < 0.05).

Conclusions: Male patients with obscured T1 slopes exhibited unique radiographic features, including higher C2–C7 SVA and diminished extension capacity. This suggests that the visibility of the T1 slope plays a pivotal role in the evaluation of cervical alignment. Furthermore, the exclusion of patients with an invisible T1 slope from research studies could lead to biased results.

Introduction: Adult spinal deformity (ASD) is prevalent among older adults, considerably affecting their quality of life. Although surgical interventions are effective, they have high complication rates and medical costs. Furthermore, there is a lack of evidence supporting the effectiveness of nonsurgical treatments (e.g., physical therapy) in patients with ASD. This study aimed to investigate the impact of "Koshimagari exercise," a specific home-based exercise regimen designed for patients with ASD, and to evaluate its effects on clinical outcomes in older adults.

Methods: A total of 144 participants aged 50–80 years with chronic low back pain (LBP) due to spinal deformities were included in this multicenter prospective study. Qualified physiotherapists conducted intervention sessions at the hospital once a week, and self-exercise was performed at home three times a week. After 3 months, the frequency of self-exercise at home increased to four times a week. Clinical evaluations were conducted using the Oswestry Disability Index (ODI), five-level classification system of EuroQol-5 Dimensions (EQ-5D), Japanese edition of Scoliosis Research Society-22r (SRS-22r), and visual analog scale (VAS) for LBP at baseline and 3, 6, and 12 months. Radiographic evaluations were performed in standing and supine positions.

Results: Of 130 participants who provided written informed consent, 98 completed the 6-month follow-up and were included in the analysis. Significant improvements observed in ODI, EQ-5D, and VAS scores were observed at 3 months, with SRS-22r scores improving throughout the study period. Radiographically, there were significant differences in the sagittal vertical axis and pelvic tilt at 12 months. Sufficient compliance with the self-exercise program was reported by 96%, 86%, and 73% of participants at 3, 6, and 12 months, respectively.

Conclusions: The "Koshimagari Exercise" program led to significant short-term improvements in health-related quality of life and pain among elderly patients with ASD. This home-based self-exercise program is an excellent nonsurgical treatment option for patients with ASD.