The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria
for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic
Pathology from Japan (JSTP), Europe (ESTP), Great Britain (BSTP) and North America (STP)
to develop an internationally-accepted nomenclature for proliferative and
non-proliferative lesions in laboratory animals. The primary purpose of this publication
is to provide a standardized nomenclature for characterizing lesions observed in the
cardiovascular (CV) system of rats and mice commonly used in drug or chemical safety
assessment. The standardized nomenclature presented in this document is also available
electronically for society members on the internet (http://goreni.org). Accurate and
precise morphologic descriptions of changes in the CV system are important for
understanding the mechanisms and pathogenesis of those changes, differentiation of natural
and induced injuries and their ultimate functional consequence. Challenges in nomenclature
are associated with lesions or pathologic processes that may present as a temporal or
pathogenic spectrum or when natural and induced injuries share indistinguishable features.
Specific nomenclature recommendations are offered to provide a consistent approach.
Stacey Fossey, John Vahle, Philip Long, Scott Schelling, Heinrich Ernst, Rogely Waite Boyce, Jacquelin Jolette, Brad Bolon, Alison Bendele, Matthias Rinke, Laura Healy, Wanda High, Daniel Robert Roth, Michael Boyle, Joel Leininger
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for
Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is an initiative of the
Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan
(JSTP) and North America (STP) to develop an internationally accepted nomenclature for
proliferative and nonproliferative lesions in laboratory animals. The purpose of this
publication is to provide a standardized nomenclature for classifying microscopic lesions
observed in the skeletal tissues and teeth of laboratory rats and mice, with color
photomicrographs illustrating examples of many common lesions. The standardized
nomenclature presented in this document is also available on the internet
(http://www.goreni.org/). Sources of material were databases from government, academic and
industrial laboratories throughout the world.
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