Annual Meeting of the Japanese Society of Toxicology

Annual Meeting of the Japanese Society of Toxicology

Search

Search
Browse

All issues

Predecessor

The 40th Annual Meeting of the Japanese Society of Toxicology

Displaying 301-350 of 368 articles from this issue

Download citation

Show all abstracts

|<
<
2
3
4
5
6
7
8
>
>|

Poster Session

Comparison of drug absorbability in various transdermal administrations and skin conditions in GÖttingen miniature pigs

Kazumori ENDOU, Hiroyuki OGURA, Hiroyuki ISHII, Hidekatsu HOSODA, Kats ...

Session ID: P-132
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2002132.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1616K)
The use of mast cells derived from CD34⁺ hematopoietic stem cells as a tool for predicting pseudoallergic drug hypersensitivity reactions

Tetsuki KATO, Jessica WHRITENOUR, Caleb HOMISKI, Keith HASKELL, Mark T ...

Session ID: P-133
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2002133.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1651K)
Detection of acquired immunosuppressive effects induced by short term oral exposure to combined environmental chemicals

Tomoki FUKUYAMA, Risako NISHINO, Tadashi KOSAKA, Koichi HAYASHI, Yuko ...

Session ID: P-134
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2002134.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1651K)
Rat immunocyte analysis for TDAR test using lymphocyte subsets

Ken GOTO, Junichiro SUGIMOTO, Akira OKAMURO, Kenichi FUJISAWA, Hidekaz ...

Session ID: P-135
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2002135.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1617K)
Local lymph node assay sensitized with two nano-particle sizes of platinum

Tomomi MORIMURA, Takayuki SEKI, Yutaka TAKAOKA, Satoko AOKI, Takeshi M ...

Session ID: P-136
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2002136.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1617K)
Immunosuppressive potential of bardoxolone methyl in mice

Mika KITSUKAWA, Hiromi TSUCHIYAMA, Akihisa MAEDA, Keiyu OSHIDA, Yohei ...

Session ID: P-137
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2002137.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1681K)
Cellular choice between autophagy and apoptosis induced by the increase of ER-stress is regulated by ATF4 expression and moreover CHOP expression

Hiroki MATSUMOTO, Noboru IWASAKI, Hiroshi NAKAGAWA, Kazuhiko NISHIMUR ...

Session ID: P-138
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003138.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1680K)
Validation of a short-term prediction system for carcinogenicity (CARCINOscreen^®) using dataset of toxicogenomics project

Hiroshi MATSUMOTO, Fumiyo SAITO, Masahiro TAKEYOSHI

Session ID: P-139
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003139.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1617K)
Time course analysis of zone specific gene expression profiles of kidney in 28-day repeated dose study in SD rats of 2-Amino-4-nitrophenol.

Fumiyo SAITO, Hiroshi MATSUMOTO, Toshio KOBAYASHI, Satsuki HOSHUYAMA, ...

Session ID: P-140
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003140.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1617K)
Transcriptomic analysis of mechanism of 2-(2'-Hydroxy-3',5'-di-tert-butylphenyl)benzotriazole induced liver toxicity

Atsushi ONO, Mutsuko HIRATA, Kato HIROHITO, Ise RYOTA, Akihiko HIROSE

Session ID: P-141
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003141.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1653K)
Relationship between regional variation of renal miRNA expression and nephrotoxicity

Keiichi MINAMI, Takeki UEHARA, Chiaki KONDO, Kou OMURA, Masayuki KANKI ...

Session ID: P-142
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003142.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1653K)
Construction of a prediction model for immune-related compounds

Yoshinobu IGARASHI, Noriyuki NAKATSU, Hiroshi YAMADA

Session ID: P-143
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003143.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1615K)
Investigation of non-linear toxicokinetcs at higher doses: Interpretation for absorption process by simultaneous oral and intravenous-administration with deuterated analog and using the bile-duct cannulated rats

Yumiko NORITAKE, Hitomi SHIMODA, Shigehito TAKESHITA, Hideki SAGISAKA, ...

Session ID: P-144
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003144.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1615K)
Identification of acetaminophen photoproduct by UVC and evaluation of the toxicity

Kohei KAWABATA, Kazumi SUGIHARA, Seigo SANOH, Shigeyuki KITAMURA, Shig ...

Session ID: P-145
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003145.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1682K)
Anticeptic isothiazoline derivatives activate human TRPA1 and TRPV1 channels

Toshiko TANAKA-KAGAWA, Shunsuke NAKAMORI, Susumu OHKAWARA, Yoko OKAMOT ...

Session ID: P-146
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003146.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1682K)
Effects of polycyclic aromatic hydrocarbons on airway epithelial cells and their mechanisms

Eiko KOIKE, Rie YANAGISAWA, Hirohisa TAKANO

Session ID: P-147
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003147.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1615K)
Distribution of perfluorocarboxylic acid in Nagase analbuminemic rats

Naomi KUDO, Masayuki KAMATA, Asuna HASHIMOTO, Yoichi KAWASHIMA

Session ID: P-148
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003148.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1615K)
Involvement of cPLA2α in the manifestation of dioxin toxicity

Nozomi FUJISAWA, Wataru YOSHIOKA, Chiharu TOHYAMA

Session ID: P-149
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003149.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1697K)
Development of human ALT-1 ELISA system to detect human hepatotoxicity in chimeric mice with humanized liver

Chise TATENO, Hiroko IWANARI, Takashi SHIMADA, Tatsuji KIMURA, Yumiko ...

Session ID: P150
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003150.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1697K)
Organotin-induced endoplasmic reticulum stress and its mechanism

Midori ISOMURA, Kyoichi MASUDA, Yaichiro KOTAKE, Shigeru OHTA

Session ID: P-151
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003151.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1645K)
Identification of Te-containing metabolite in garlic by HPLC-ICP-MS and HPLC-ESI-MS-MS

Yasumi ANAN, Miyuki YOSHIDA, Saki HASEGAWA, Maki TOKUMOTO, Yasumitsu O ...

Session ID: P-152
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003152.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1645K)
Transcriptional regulation of MTF-1 target genes by the chromatin remodeling factor, Snf2H

Takuomi HOSAKA, Yuuichi ITEZONO, Kazuya OKADA, Tomoki KIMURA, Hiroyuki ...

Session ID: P-153
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003153.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1616K)
Brain-specific induction of expression of genes by methylmercury in mice

Min-seok KIM, Takahiro SAITO, Tsutomu TAKAHASHI , Jin-yong LEE, Gi-wo ...

Session ID: P-154
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003154.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1615K)
Effects of methylmercury on food allergy mice

Ryosuke NAKAMURA, Yuka SONE, Masako KIYONO

Session ID: P-155
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003155.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1661K)
Examination of the usefulness of in vitro hepatotoxicity assay using HepaRG cells

Takafumi TOMIDA, Hayao OKAMURA, Masahiro SATSUKAWA

Session ID: P-156
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003156.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1661K)
Mechanism analysis of cytotoxicity of acyl glucuronide

Taishi MIYASHITA, Tatsuki FUKAMI, Miki NAKAJIMA, Tsuyoshi YOKOI

Session ID: P-157
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003157.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1654K)
Culture medium type affects biological response of multi-walled carbon nanotubes in BEAS-2B cells

Hisao HANIU, Naoto SAITO, Yoshikazu MATSUDA, Kayo MARUYAMA, Yuki USUI, ...

Session ID: P-158
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003158.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1654K)
Effect of etanol on erythropoietin production in HepG2 Cell

Kazuhiko NISHIMURA, Hideaki KATSUYAMA, Masahiro HIRAOKA, Hiroshi NAKAG ...

Session ID: P-159
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003159.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1699K)
Correlation between in vivo hepatotoxicity and in vitro cytotoxicity/toxicokinetics/chemical properties

Kazunori FUJIMOTO, Kazumi ITO, Takayoshi NISHIYA, Yoshimasa KOBAYASHI, ...

Session ID: P-160
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003160.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1698K)
Regulatory mechanism of neointimal formation after vascular injury by transcription factor Nrf2 via inhibiting ROS—ERK pathway

Takashi ASHINO, Masayuki YAMAMOTO, Takemi YOSHIDA, Satoshi NUMAZAWA

Session ID: P-161
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003161.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1648K)
Cytotoxicity evaluation of environmental chemicals via free radical detection using immuno-spin trapping, In-Cell Western and confocal microscopy

Yuya HORINOUCHI, Fiona A. SUMMERS, Marilyn EHRENSHAFT, Toshiaki TAMAKI ...

Session ID: P-162
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003162.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1647K)
Effect of the natural antioxidant, dimerumic acid on mitochondrial oxidative stress

Naoki IMAIZUMI, Ai TOKESHI, Sumino GOYA, Akiko UEHARA, Shugo SAKIHAMA, ...

Session ID: P-163
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003163.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1645K)
Analysis of strain differences in TNBS-induced mice colitis models

Yumiko MIZUKAWA, Ikumi HASHIMOTO, Miki KAMATANI, Yurie SANO, Yuki SATO ...

Session ID: P-164
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003164.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1644K)
Toxicity assessment of glycine soja (Soybean) peptide-B;13-week oral dose study in sprague-dwley rats

Kang-Hyun HAN

Session ID: P-165
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003165.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1642K)
Effect of SiO₂ and TiO₂ nanoparticles on the cytotoxicity of metal salts

Kazuo ISAMA, Tsuyoshi KAWAKAMI, Atsuko MIYAJIMA, Atsuko MATSUOKA

Session ID: P-166
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003166.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1642K)
Toxicokinetics of sub-nanomaterials following oral administration for safety evaluation

Kazuma HIGASHISAKA, Miyuki UJI, Manami YAMAGUCHI, Kazuki MISATO, Shin- ...

Session ID: P-167
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003167.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1614K)
An advanced multidimensional scheme of safety assessment for nano scale materials

Masamichi KAMINISHI, Takayuki ANZAI, Tetsuo SATO

Session ID: P-168
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003168.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1614K)
A basic study on involvement of particles in the brain diseases: Quantitative evaluation of transfer of nanomaterials into the brain

Kota TANAKA, Kazuma HIGASHISAKA, Takashi NAGANO, Akiyoshi KUNIEDA, Yuk ...

Session ID: P-169
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003169.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1617K)
Ecotoxicity evaluation for single- and multi-walled carbon nanotubes

Hisashi HASHIMOTO, Kikuo YOSHIDA, Sawae OBARA, Atsuo KISHIMOTO

Session ID: P-170
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003170.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1617K)
Biological effects of titanium dioxide by intratracheal administration

Masaaki SUZUKI, Hirokazu KANO, Hideki SENOH, Hitomi KONDO, Tadao TOYA, ...

Session ID: P-171
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003171.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1615K)
The study of th interaction in silver nanoparticles and medicines.

Haruka WATARAI, Katsuhiro ISODA, Shino MINOMO, Toyohiro AONO, Masakats ...

Session ID: P-172
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003172.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1615K)
Teratogenic study of nanomaterials in mice

Tomoko FUJITANI, Hiroshi ANDO, Yoshikazu KUBO, Akiko INOMATA, Akio OGA ...

Session ID: P-173
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003173.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1651K)
Influence of silica nanoparticles on urate transport via organic anion transporter URAT1

Yuuki TAMURA, Daisaku MIURA, Jutabha PROMSK, Naohiko ANZAI, Ken-ichi K ...

Session ID: P-174
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003174.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1651K)
Identification of novel biomarkers for drug-induced renal papillary necrosis in rats by toxicoproteomics

Daisuke SASAKI, Masayuki KANKI, Kumiko NISHIHARA, Masashi HIRAMOTO, Ma ...

Session ID: P-175
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003175.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1618K)
Time-course change of renal lesions in a 28-day oral toxicity study of 2-amino-4-nitrophenol in male rats.

Toshio KOBAYASHI, Yutaka OSHIMA, Takayuki KOGA, Hiroshi MATSUMOTO, Fum ...

Session ID: P-176
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003176.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1618K)
Change of drug transporter mRNAs by gentamicin treatment in rat kidney

Kazuya TSUTSUMI, Sayaka YOSHIDA, Masayuki OHABAYASHI, Noriko KOHYAMA, ...

Session ID: P-177
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003177.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1615K)
PBN reduces acute uranium nephrotoxicity by inhibiting uranium-deposition to mouse kidney

Yasushi OHMACHI, Tomomi IMAMURA, Mizuyo IKEDA, Tsuyoshi ITOH, Eriko SH ...

Session ID: P-178
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003178.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1615K)
Maximizing exposure on non-clinical inhalation studies of benign pulmonary drugs

Christopher BANKS, Márta GRÓSZ, David J ESDAILE

Session ID: P-179
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003179.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

To minimize concurrent dermal or oral ingestion of test article, nose-only inhalation exposure is now routinely used in inhalation laboratories. However, this exposure procedure requires the restraint of rodents, for periods of up to four hours (accepted maximum).
Pulmonary pharmaceutical products (surfactants for fetal atelectasis or mucolytic medications for cystic-fibrosis, for example) may be administered to humans at high volumes or for long periods of time.
Non-clinical testing to support the human use of these products must also reach high dosages to provide sufficient safety margins.
Calculation of a Maximum Feasible Dose requires: the respiratory minute volume (RMV) - a measured
or calculated value fixed by the body weight of the rat; the chamber concentration of active ingredient - limited by the fixed formulation concentration; and efficient atmosphere generation - optimized during
technical trials. When testing benign pulmonary drugs, the normal four hour exposure must be increased.
At CiToxLAB Hungary, exposures of up to eight hours each day have been used on subacute studies. However, it is critical to ensure that the potential stress of spending 33% of each 24 hour period within restraint tubes does not adversely impact the health status of the animals and compromise the study. We have compared various parameters for control animals restrained for the regular four hours per day with those from animals restrained for the eight hour period each day. There were no significant differences in bodyweight gain, food consumption or microscopic findings that could be ascribed to this prolonged period of restraint.

View full abstract

Download PDF (1649K)
Hepatotoxicity assessment using HepG2 spherioids in a micro-space cell culture system

Satoru AYANO, Yusuke HASEGAWA, Naoto FUKUHARA, Yoko EJIRI, Masaya HOSO ...

Session ID: P-180
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003180.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1649K)
Influence on ability of spontaneous activity by malodorous substance in mice

Hitomi NAKAMURA, Junya TATSUNO, Makiko Yonehara, Shin Takehara, Yasue ...

Session ID: P-181
Published: 2013
Released on J-STAGE: August 14, 2013

DOIhttps://doi.org/10.14869/toxpt.40.1.0.2003181.0

CONFERENCE PROCEEDINGS FREE ACCESS

Show abstractHide abstract

[in Japanese]

View full abstract

Download PDF (1651K)

|<
<
2
3
4
5
6
7
8
>
>|

Top