Annual Meeting of the Japanese Society of Toxicology

Annual Meeting of the Japanese Society of Toxicology

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The 43rd Annual Meeting of the Japanese Society of Toxicology

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Symposium 18

On the toxicological significance of heme oxygenase induction

Takemi YOSHIDA

Session ID: S18-1
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S18-1

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The epidemiology and clinical feature of acute carbon monoxide poisoning

Ken ISEKI

Session ID: S18-2
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S18-2

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Carbon monoxide toxicity in forensic practices: Friend? or foe ?

Ken-ichi YOSHIDA

Session ID: S18-3
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S18-3

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PGRMC1/Sigma-2 receptor as a novel CO-responsive sensor

Makoto SUEMATSU, Yasuaki KABE

Session ID: S18-4
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S18-4

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Hyperbaric oxygen therapy on carbon monoxide poisoning

Isotoshi YAMAMOTO, Sinji NAKAMARU, Tsuyoshi SAITO, Tomoatsu TSUJI, Hir ...

Session ID: S18-5
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S18-5

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Symposium 19

Natural history of renal tubular dysfunction in inhabitants of the cadmium-polluted Jinzu river basin in Toyama prefecture, Japan: A 27-year follow-up study

Keiko AOSHIMA

Session ID: S19-1
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S19-1

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Current status of oral exposure to cadmium and its hazardous effects in farmers in Akita prefecture─the forgotten cadmium-polluted area

Hyogo HORIGUCHI

Session ID: S19-2
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S19-2

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Development of a new rice variety 'Koshihikari Kan No.1' with low cadmium

Satoru ISHIKAWA

Session ID: S19-3
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S19-3

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Novel approach for elucidation of transport and toxicity of cadmium in kidney

Seiichiro HIMENO, Satoko HAMAO, Hazuki YAMAMOTO, Hitomi FUJISHIRO

Session ID: S19-4
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S19-4

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Cadmium toxic mechanism through suppression of gene expression

Jin-Yong LEE, Maki TOKUMOTO, Masahiko SATOH

Session ID: S19-5
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S19-5

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Symposium 20

A comprehensive in vivo model for evaluation of genotoxicity and carcinogenicity of chemicals

Hideki WANIBUCHI, Masaki FUJIOKA, Min GI

Session ID: S20-1
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S20-1

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Approach to the prediction of chemical carcinogenicity using reporter gene-transgenic animals

Takashi UMEMURA

Session ID: S20-2
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S20-2

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Detection of hepatocarcinogens by combination of liver micronucleus assay and histopathological examination in 4-week repeated dose studies

Shuichi HAMADA

Session ID: S20-3
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S20-3

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Bhas 42 cell transformation assay to improve prediction of genotoxic and non-genotoxic carcinogens

Kiyoshi SASAKI

Session ID: S20-4
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S20-4

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A role of genotoxicity test for setting the environmental quality standard and the guideline value of hazardous chemicals in air

Yasunobu AOKI

Session ID: S20-5
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S20-5

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Risk assessment of genotoxic carcinogens

Masamitsu HONMA, Ken-Ichi MASUMURA, Takeshi MORITA

Session ID: S20-6
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S20-6

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Symposium 21

Clinical proarrhythmic risk assessment from the safety pharmacology and non-clinical studies

Chieko KASAI

Session ID: S21-1
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S21-1

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Non-clinical cardiovascular toxicology using in silico approaches

Junko KUROKAWA, Takashi ASHIHARA, Yasunari KANDA, Shushi NAGAMORI, Kaz ...

Session ID: S21-2
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S21-2

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ECG based cardiac safety assessment of drugs in clinical trials

Kaori SHINAGAWA

Session ID: S21-3
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S21-3

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Clinical evaluation on cardiovascular adverse event and feedback to non-clinical field

Ichiro NAKAOKA

Session ID: S21-4
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S21-4

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Open discussion/Q&A

Masafumi DOI, Asuka TAKUMI, Hidenori MIYATA, Makoto MIYAUCHI, Ken-ichi ...

Session ID: S21-5
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_S21-5

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Workshop 1

Why was the certifying toxicologist necessary?

Shuji TSUDA

Session ID: W1-1
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W1-1

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Current status and challneges of the DJSOT system

Mamoru MUTAI

Session ID: W1-2
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W1-2

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Activity of the IUTOX toxicology recognition task force

Akihiko HIROSE

Session ID: W1-3
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W1-3

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Systems for certified toxicologist (DABT) in the US

Shoji ASAKURA

Session ID: W1-4
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W1-4

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Workshop 2

Introduction

Shigeru HISADA

Session ID: W2-1
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W2-1

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Background and objective of prospective evaluation to justify proceeding with revision of the ICH S1 guidelines

Mizuho NONAKA

Session ID: W2-2
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W2-2

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Status report of carcinogenicity assessment documents (CADs) in prospective evaluation

Kumiko OGAWA

Session ID: W2-3
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W2-3

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Overview of pharmacology-induced mechanisms of carcinogenesis by drug classes based on the analysis of the data set from the three parties

Jan Willem VAN DER LAAN, Peter KASPER, Beatriz SILVA LIMA, David JONES ...

Session ID: W2-4
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W2-4

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Predicting the outcome of life-time carcinogenicity studies in rats based on chronic (6-month) toxicity studies in this species is possible in some instances. This should reduce the number of such studies and hence have a significant impact on the total number of animals used in safety assessment of new medicines. From a regulatory perspective, this should be sufficient to grant a waiver for a carcinogenicity study in those cases where there is confidence in the outcome of the prediction.
Pharmacological properties are a frequent key factor for the carcinogenic mode of action of some pharmaceuticals, but data-analysis on a large dataset has never been formally conducted. We have conducted an analysis of a dataset from based on the perspective of the pharmacology of 255 compounds from industrial and regulatory sources.
It is proposed that a pharmacological, class-specific, model may consist of an overall causal relationship between the pharmacological class and the histopathology findings in rats after 6 months treatment, leading to carcinogenicity outcome after 2 years. Knowledge of the intended drug target and pathway pharmacology should enhance the prediction of either positive or negative outcomes of rat carcinogenicity studies.
The goal of this analysis is to review the pharmacological properties of compounds together with the histopathology findings from the chronic toxicity study in rodents in order to introduce an integrated approach to estimate the risk of human carcinogenicity of pharmaceuticals.

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Literature research-based overview of pharmacology-induced carcinogenesis in each of the tumor target tissues with risk assessment in humans, (1) Non-endocrine tumors

Kenjiro TSUBOTA

Session ID: W2-5
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W2-5

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Literature research-based overview of pharmacology-induced carcinogenesis in each of the tumor target tissues with risk assessment in humans, (2) Endocrine tumors

Takanori IKEDA

Session ID: W2-6
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W2-6

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Pharmacology-based tumor prediction of pharmaceuticals -Its possibility and challenge-

Toyohiko AOKI

Session ID: W2-7
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W2-7

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Workshop 3

Effect of pesticides on honeybee: current problem and prevenation

Jun NAKAMURA

Session ID: W3-1
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W3-1

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Molecular mechanism of insect selective toxicity of neonicotinoids

Kazuhiko MATSUDA

Session ID: W3-2
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W3-2

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Elucidation of neonicotinoids exposure to human: Determination of urinary neonicotinoid pesticides and its metabolites

Yoshinori IKENAKA, Mayumi ISHIZUKA

Session ID: W3-3
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W3-3

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Workshop 4

Survey of risk literacy for medicine in non-experts

Ryuki HANAOKA, Atsushi SADAMATSU, Arisa EMA, Akashi TANAKA, Tetsuro TA ...

Session ID: W4-1
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W4-1

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Investigations into communication system of medical drug risk in Japan

Yoshiyuki HIRONO, Ryuki HANAOKA, Atsushi SADAMATSU, Arisa EMA, Akashi ...

Session ID: W4-2
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W4-2

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Pharmacists' perspectives on risk communication

Satoko KATSURAGI

Session ID: W4-3
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W4-3

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Risk communication of Kampo (Traditional Japanese Medicine): Risk communication analysis at the fields of medicine, welfare and care by risk perception and risk management in contemporary Japan

Tetsuro TANOJIRI

Session ID: W4-4
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W4-4

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Considering risk communication from other areas' viewpoint

Atsushi SADAMATSU

Session ID: W4-5
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W4-5

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Workshop 5

Early virtual/in vitro/in vivo toxicity profiling for effective toxicity mitigation strategy setting

Kazunori FUJIMOTO, Yoshimasa KOBAYASHI, Takayoshi NISHIYA, Kiyoshi TAK ...

Session ID: W5-1
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W5-1

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Early stage safety assessment for safer new drug

Motohiro SHIOTANI, Kyoko NAKANO, Shoji ASAKURA, Kohei SAWADA, Satoshi ...

Session ID: W5-2
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W5-2

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A safety assessment strategy started with lead profiling in drug discovery

Kenichi HANIOKA, Akinobu OKADA

Session ID: W5-3
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W5-3

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The role of explorative evaluation on safety profile at early stage drug discovery through selection of drug candidate

Jiro DEGUCHI, Izuru MIYAWAKI

Session ID: W5-4
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W5-4

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Case examples of in vitro/in vivo screening strategies in order to select the most promissing compounds for development within limited time

Kiyohiro HASHIMOTO

Session ID: W5-5
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W5-5

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Workshop 6

Outline of a plan for Japanese Project “ARCH-Tox” for the future chemicals management policy: Research and development of in vitro and in vivo assays for internationally leading hazard assessment and test methods

Hajime KOJIMA

Session ID: W6-1
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W6-1

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Mechanism-based evaluation system for hepato- and nephrotoxicity using gene expression analysis

Fumiyo SAITO

Session ID: W6-2
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W6-2

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Challenge to short-term prediction method for chemical carcinogenicity by gene expression analysis

Hiroshi MATSUMOTO

Session ID: W6-3
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W6-3

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Developement of in vitro hepatotoxicity assay by means of continuous monitoring of multiple luciferases

Yoshihiro NAKAJIMA

Session ID: W6-4
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W6-4

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In vivo nephrotoxicity assay using reconstituted 3-dimensional kidney-like structure

Tetusya OHBAYASHI

Session ID: W6-5
Published: 2016
Released on J-STAGE: August 08, 2016

DOIhttps://doi.org/10.14869/toxpt.43.1.0_W6-5

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