Novel Lipoxygenase Inhibitors, Tetrapetalone B, C, and D from Streptomyces sp.

Abstract

Three novel lipoxygenase inhibitors, tetrapetalone B (2, C₂₈H₃₅NO₉), C (3, C₂₆H₃₄NO₈), and D (4, C₂₈H₃₆NO₁₀), were isolated from a culture broth of Streptomyces sp. USF-4727 that produced a lipoxygenase inhibitor tetrapetalone A (1) simultaneously. Each chemical structure was revealed by spectroscopic evidence, this suggests that these three compounds are structurally related to 1. They had a tetracyclic skeleton and a β-D-rhodinosyl moiety. Tetrapetalone B, C, and D inhibited soybean lipoxygenase with IC₅₀: 320, 360, and 340 μM respectively.