Candidusin A and B: New p-Terphenyls with Cytotoxic Effects on Sea Urchin Embryos

Abstract

Two new metabolites exhibiting an inhibitory activity against the development of sea urchin embryos were isolated from the culture of Aspergillus candidus Link. The structures of the compounds, candidusin A and B, were determined on the basis of chemical and spectroscopic means. Candidusin B inhibited DNA and RNA synthesis but not protein synthesis.