Tigliane Type Diterpene-esters with Epstein-Barr Virus-inducing Activity from Sapium sebiferum

Hajime OHIGASHI; Takanao OHTSUKA; Mitsuru HIROTA; Koichi KOSHIMIZU; Harukuni TOKUDA; Yohei ITO

doi:10.1271/bbb1961.47.1617

Agricultural and Biological Chemistry

Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369

Tigliane Type Diterpene-esters with Epstein-Barr Virus-inducing Activity from Sapium sebiferum

Hajime OHIGASHI, Takanao OHTSUKA, Mitsuru HIROTA, Koichi KOSHIMIZU, Harukuni TOKUDA, Yohei ITO

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JOURNAL FREE ACCESS

1983 Volume 47 Issue 7 Pages 1617-1622

DOI https://doi.org/10.1271/bbb1961.47.1617

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Abstract

Three Epstein-Barr virus activating principles have been isolated from the leaves of Sapium sebiferum (Euphorbiaceae), which is one of commonroadside and garden trees in Japan. By chemical and spectroscopic evidence they were identified as tigliane type diterpeneesters with the structures of 1, 2 and 3. 1 and 2 strongly induced an early antigen of the virus in a Raji cell, while 3 did so weakly. The activity of some derivatives of 2 are also discussed.

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